基于CELLSEARCHTM系统的乳腺癌循环肿瘤细胞临床研究概览#br# #br#

乳腺癌是女性人群常见的恶性肿瘤，检测循环肿瘤细胞（CTCs）在乳腺癌患者中的临床价值已成为近年的研究热点之一。当前CTCs的检测方法种类繁多，但方法学差异带来的异质性问题却制约了研究数据的对比与分析。较早上市的CELLSEARCHTM系统仍是目前检测CTCs的“金标准”方法，多数CTCs相关临床研究正是基于这一检测方法。因此，本文仅对基于CELLSEARCHTM系统的乳腺癌CTCs临床研究进行复习、分类与综述，以获得具有可比性的乳腺癌CTCs临床研究概览。

Overview of clinical studies on circulating tumor cells in breast cancer based on CELLSEARCH system#br# #br#

Breast cancer is a common malignant tumor in women. The clinical value of circulating tumor cell （CTCs） in breast cancer has become one of the focuses in recent years. There are many CTCs detection methods at present leading to huge heterogeneity which limits the widely use of research data. Nowadays， the ‘golden standard’ of CTCs detection method is still the commercial detection system named CELLSEARCH and most of the clinical studies have adopted this system. This paper will only summarize the clinical study of breast cancer CTCs based on CELLSEARCH system with the heterogeneity caused by methodological inconsistencies being avoided.