减重干预对超重与肥胖成人代谢指标的影响

目的观察减重干预对超重、肥胖成人代谢指标的影响。方法在2008年3月至2009年12月我院体检社区人群中，人选排除高血压、糖尿病且未曾服用过于预血压、血脂及血糖药物、自愿接受减重干预的超重、肥胖成人共116例，按年龄分为青年组、中壮年组、老年组，对各组实施为期6个月的强化健康教育、膳食、运动管理等综合减重干预措施，分别对干预前后的体质指数（BMI）、体脂率、血压、空腹血糖、口服75g葡萄糖2h后血糖（OGTT 2h血糖）、血清三酰甘油（TG）、总胆固醇、高密度脂蛋白胆固醇（HDL）及低密度脂蛋白胆固醇（LDL）的测值进行t检验。结果干预后各组BMI、空腹血糖、TG及LDL均较干预前明显下降（P〈0．05）；各组HDL较干预前明显上升（P〈0．05）；青年组、中壮年组干预后体脂肪率、收缩压、舒张压及OGTT 2h血糖均较干预前明显下降（P〈0．05），但老年组干预后体脂肪率、收缩压、舒张压及OGTT 2h血糖与干预前差异无统计学意义。结论减重干预可有效改善各年龄段超重、肥胖成人的体格及代谢指标，降低肥胖相关疾病的患病风险，是超重肥胖人群防病健身安全可靠的有效方法；老年超重、肥胖人群在减重干预的同时应尽早结合药物治疗。

Impact of weight-loss intervention on metabolic indicators in over-weight or obesity adults

Objective To investigate the effects of weight-loss intervention on metabolic indicators in over-weight or obesity adults. Methods A total of 116 over-weight or obese adults entered into this study from March 2008 to December 2009. The participants were divided into three groups by age. Each group received 6 months＇ weight-loss intervention. Body mass index （BMI）, body fat rate, blood pressure, fasting blood glucose （FBG） ,oral glucose tolerance test （OGTY） 2 h blood glucose,serum triglyceride （TG） ,total cholesterol （TC）, high-density lipoprotein cholesterol （HDL-C）, and low-density lipoprotein cholesterol （LDL-C） were measured before and after the intervention, The data were analyzed using t test. Results After the intervention, BMI, FBG, TG, and LDL-C were significantly decreased while HDL was significantly increased in each group （ P 〈 0. 05 ）. Body fat rate, systolic blood pressure, diastolic blood pressure and OG＇IT 2 h blood glucose were significantly reduced in the young and middle-aged groups （P 〈0. 05）, however, there was not significant difference in the older-age group. Conclusions Weight-loss intervention may be effective in improving physical and metabolic indicators in adults with over-weight and obesity and reducing the risk of obesity-related diseases.