奈替米星2种给药方案血药浓度的比较

目的 :研究奈替米星不同给药方案的血药浓度、临床疗效及药物毒性。方法 :将22例下呼吸道感染患者随机分为两组 ,采用TDx法测定血药浓度 ,比较各组临床疗效 ,监测肾功能、听力。结果 :日剂量相同时 ,奈替米星1次/d给药组 (QD组 )的血药峰浓度显著高于2次/d给药组 (BD组 ) (P<0.01) ;QD组血药谷浓度均低于2μg/ml ,与BD组比较显著降低 (P<0.01) ;治疗后血清肌酐水平两组间比较有显著性差异 (P<0.05)。结论 :奈替米星1次/d给药方案较2次/d给药方案能够获得更高的峰浓度及较低的谷浓度 ,进而提高临床疗效 ,减少不良反应。

Comparison of Drug Serum Concentrations of Netilmicin between 2 Kinds of Dosage Regimen

OBJECTIVE To evaluate the clinical effects and toxicity of netilmicin with different administrations by deˉtermining its serum concentration in the treatment of lower respiratory tract infection.METHODS:22cases of lower respiˉratory tract infection were randomly divided into two groups.The drug serum concentrations were determined by TDx system.Clinical effects were compared;renal function and hearing ability were monitored.RESULTS:On the condition of the same total daily dosage,the peak concentrations in once-daily group(group QD)were significantly higher than those in twice-daily group(group BD)(P<0.01).All trough concentrations in group QD were less than2μg/ml,and they were significantly lower than those in group BD(P<0.01).The level of serum creatinine was markedly different between the two groups after administration(P<0.05).CONCLUSION:Netilmicin in a single daily dose administration results in a higher peak drug serum concentration,lower trough concentration,hence better therapeutic effects and less side effects.