| 猪囊尾蚴病患者CD4~+ CD25~+调节性T细胞水平的变化 |
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| 引用本文： | 王雪梅,王英,方强,孙新,焦玉萌,常雪莲,夏惠.猪囊尾蚴病患者CD4~+ CD25~+调节性T细胞水平的变化[J].淮海医药,2013,31(3):207-208. |
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| 作者姓名： | 王雪梅 王英 方强 孙新 焦玉萌 常雪莲 夏惠 |
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| 作者单位： | 蚌埠医学院病原生物学教研室,安徽蚌埠,233030 |
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| 基金项目： | 安徽省高校学校省级自然科学研究重点项目(KJ2013)安徽省高校学校青年教师科研资助计划项目 |
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| 摘 要： | 目的检测猪囊尾蚴病患者外周血中CD4+CD25+调节性T淋巴细胞及其FOXP3的表达情况,探讨CD4+CD25+调节性T淋巴细胞在猪囊尾蚴感染中的免疫调控作用及意义。方法采用流式细胞仪检测11例猪囊尾蚴病患者外周血中CD4+CD25+T淋巴细胞的含量,同时观察CD4+CD25+T细胞中表达FOXP3群体的百分含量。结果囊尾蚴病患者外周血中CD4+CD25+T淋巴细胞的百分含量为6.11%,较正常人(3.94%)明显升高(P<0.05);患者外周血中CD4+CD25+T细胞表达FOXP3的细胞百分含量为15.67%,与正常对照组(11.09%)有显著性差异(P<0.05)。结论猪囊尾蚴病患者外周血中CD4+CD25+T淋巴细胞的百分含量显著升高,表明CD4+CD25+调节性T细胞可能参与猪囊尾蚴感染的免疫抑制。
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| 关 键 词： | 猪囊尾蚴病 CD4+CD25+调节性 T细胞 流式细胞术 |
Variation in the level of CD4 + CD25 + T cell in peripheral blood of patients with cysticercosis |
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| Affiliation: | WANG Xue-mei , WANG Ying , FANG Qiang , et al. ( Department of Microbiology and Parasitology, Bengbu Medical College ,Anhui 233030, China ) |
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| Abstract: | Objective To detect the level ofCD4^＋CD25^＋T cells and their FOXP3-expressed subpopulation in peripheral blood of patients with cysticercosis and investigate the role and significance of CD4 ＋ CD25 ＋ T cells in immune regulation of cysticercus cellulosae infection. Methods The level of CD4^＋CD25^＋ T cells andCD4^＋CD25^＋ FOXP3＋ subsets of 11 patients with cysticercosis were detected by flow cytometry. Results The percentage of CD4^＋CD25^＋ T cells of patients （ 6.11% ） was higher than that of the controls （3.94%）. The percentage ofCD4^＋CD25^＋ FOXP3 ＋ subsets （ 15.67% ） was higher than that in the controls （ 11.09% ）. Conclusion The percentage ofCD4^＋CD25^＋ T cells was higher than that of controls remarkably. The level of CD4^＋CD25^＋OXP3＋ subsets was higher. The regulation of CIM ＋ CD25 ~ T cell may be one of the reasons leading to immunosuppression on cysticercosis. |
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| Keywords: | Cysticercosis CD4^＋CD25^＋ regulation T cell Flow cytometry |
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