异种脱细胞真皮基质对拔牙创愈合的作用

目的:评价异种(牛)脱细胞真皮基质对拔牙创愈合及牙槽嵴形态改建的作用.方法:选用18只健康成年犬,拔除双侧下颌第二前磨牙,左侧拔牙创内充填异种脱细胞真皮基质作为实验组,右侧拔牙创不处理作为对照组,同体对照;拔牙后分别于第4、12、24周各处死6只动物,头颅标本行螺旋CT扫描,应用多平面重建技术测量拔牙创CT值及牙槽嵴吸收值;切取拔牙创组织制作苏木精-伊红染色切片行组织学观察.结果:各时间点实验组拔牙创CT值均显著高于对照组(P＜0.01);实验组牙槽嵴吸收值均明显低于对照组(P＜0.05);组织学表现无明显差异.结论:异种脱细胞真皮基质可促进拔牙创愈合,保持牙槽嵴高度,有利于后期的牙种植或义齿修复.

Efficacy of Heterogeneous Acellular Dermal Matrix on the Healing of Dental Sockets

Objectives: To assess the efficacy of heterogeneous(cattle)acellular dermal matrix(ADM) on the healing of dental sockets and rebuilding of alveolar bone.Methods: 18 dogs' bilateral mandibular second premolars were extracted.The test group(left sockets) was filled with ADM,while the control(right sockets) was left without any treatment.Every 6 dogs were sacrificed at the end of 4,12 and 24 weeks.Heads of dogs were scanned by spiral CT.CT values of sockets and heights of the alveolar crest absorption were measured by multiplane reconstruction(MPR)technique.The new tissue formed in sockets were sectioned for histological observation.Results: At all time points,CT values of the sockets in the test group were significantly higher than those in the contral group(P<0.01).Heights of the alveolar crest absorption in the test group were significantly less than those in the contral group.There was no significant difference between the two groups in the histological appearance.Conclusion: Filling heterogeneous ADM in dental sockets can promote the healing of sockets,preserve the height of the alveolar crest,benefit for later dental implantation and prosthetic rehabilitation.