| 谷氨酸对伏隔核痛反应神经元放电的影响 |
| |
| 引用本文： | 张秀娟,徐满英,吕宁,闫彬彬.谷氨酸对伏隔核痛反应神经元放电的影响[J].哈尔滨医科大学学报,2002,36(6):425-427. |
| |
| 作者姓名： | 张秀娟 徐满英 吕宁 闫彬彬 |
| |
| 作者单位： | 哈尔滨医科大学生理学教研室,黑龙江,哈尔滨,150086 |
| |
| 基金项目： | 国家自然科学基金资助项目(30240058)，黑龙江省科技攻关项目(GC01Cl41-01) |
| |
| 摘 要： | 目的：研究脑室内注入谷氨酸（Glu)对伏隔核（NAcc)痛反应神经元放电的影响。方法：细胞外记录神经元放电。结果：（1）伤害性刺激可使NAcc内痛兴奋神经元（PEN）电活动增加，使痛抑制神经元（PIN）电活动减少。（2）脑室内注入Glu可命名NAcc内PEN诱发放电频率增加，潜伏期缩短；使PIN诱发放电频率减少，抑制时程延长。结论：脑室注入Glu可使NAcc内痛反应神经元对伤害性刺激的反应加强，表现出Glu易化疼痛效应。
|
| 关 键 词： | 谷氨酸 伏隔核 痛兴奋神经元 痛抑制神经元 电活动 |
| 文章编号： | 1000-1905(2002)06-0425-03 |
| 修稿时间： | 2002年7月19日 |
Effects of glutamic acid on discharge of pain-related neurons in nucleus accumbens |
| |
| ZHANG Xiu-juan,XU Man-ying,LU Ming,et al.Effects of glutamic acid on discharge of pain-related neurons in nucleus accumbens[J].Journal of Harbin Medical University,2002,36(6):425-427. |
| |
| Authors: | ZHANG Xiu-juan XU Man-ying LU Ming |
| |
| Abstract: | Objective To study the influence of intracerebroventricular injection of glutamic acid(Glu) on discharge of pain-related neurons in nucleus accumbens(NAcc) .Methods The discharge frequency of neurons was recorded by extracellular recording. Results (1)The noxious stimulation increased the electric activities of pain-excitation neurons(PEN) and decreased the electric activities of pain-inhibition neurons(PIN) . (2)The intracerebroventricular injection of Glu caused an increase of the evoked discharge frequency of PEN and the shortening of latency as well as a reduction of the evoked discharge frequency of PIN and a prolongation of inhibitory duration. Conclusion The response of pain-related neurons in NAcc on the noxious stimulation is potentiated by the intracerebroventricular injection of Glu, i.e. exhibiting the excited pain effect of Glu. |
| |
| Keywords: | glutamic acid nucleus accumbens pain-excitation neurons pain-inhibition neurons electric ac- tivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
