Ⅱ型糖尿病小鼠对镉金属硫蛋白致肾脏毒性的易感性

目的]探讨Ⅱ型糖尿病小鼠对重复性镉金属硫蛋白（CdMT)染毒致肾脏损伤的易感性。方法]18只6月龄雄性Ⅱ型糖尿病小鼠（Umea ob/ob小鼠）和18只同种系非Ⅱ型糖尿病的雌性瘦型小鼠（正常小鼠），各自随机分为3个组，采用背部皮下注射方式染毒。为了使两种类型小鼠肾皮质中达到相似的染镉浓度，根据两种小鼠肾脏体系数之比值来确定不同的CdMT染毒剂量。结果]ob/ob小鼠尿NAG、尿钙及肾皮质钙含量在低肾皮质镉剂量时升高，而瘦型小鼠在试剂量时的相应指标无明显改变。结论]本研究提示Ⅱ型糖尿病小鼠对镉的肾脏毒性易感。

The Susceptibility of Type-2 Diabetic Mice to Cadmium metallothionein induced Nephrotoxicity

Objective] The aim of this study was to investigate the susceptibility of type 2 diabetic mice (Umea ob/ob mice) to cadmium metallothionein (CdMT) induced nephrotoxicity. Methods] 18 of female ob/ob mice and 18 of their lean litter mates (normal mice) were randomly divided into three groups for each type,and administered subcutaneously with CdMT 5 times in short interval. The different doses of CdMT were given to both types of mice based on the ratio of kidney weight to body weight in order to reach the same level of cadmium in renal cortex. Results] The significant increase in NAG and calcium in urine and in renal cortex was found at the lower level of cadmium in renal cortex in ob/ob mice than in normal mice. Conclusion] The authors concluded that ob/ob mice were more susceptible to CdMT induced renal damage.