食管癌放射治疗联合化疗疗效观察

目的：观察食管癌放射治疗联合DF方案化疗的临床疗效和毒副反应。方法：将符合入组条件的92例食管癌患者随机分为单纯放疗组（46例）和放化组（46例）。单纯放疗组采用6MVX直线加速器常规照射,每次1.8-2Gy,每周5次,照射剂量为60～70Gy。放化组外照射同常规放疗组,放射治疗当日开始采用DF方案化疗：氟尿嘧啶（5-FU）500mg/d,d1-5;顺铂（DDP）20mg/d,d1-5,28天一个疗程,每例至少化疗2疗程后评价疗效,共用2～4疗程。结果：放化组和单放组缓解率分别为82.6%和58.7%（P〈0.05）。结论：放射治疗联合DF方案化疗,疗效优于单纯放疗,毒副反应可以耐受,是治疗食管癌的有效方法。

Observation of the efficacy of chemotherapy combined with radiotherapy for esophageal cancer

Objective:To observe the results and side effects of chemotherapy with DF combined with radiotherapy in treatment of esophageal cancer.Methods:A prospective randomized trial on chemotherapy (C) with DF(Cisplatin +fluorouracil)combined with radiotherapy(R) for esophageal cancer was carried out in 92 patients.The patients were randomized into combined group (R+C,46 patients) or radiotherapy alone group (R,46 patients).6MV photon was used for all patients,each 1.82Gy,5 times a week,irradiation dose 6070Gy.combined group with conventional external beam radiotherapy,radiation therapy began the day with DF regimen: fluorouracil (5FU) 500mg / d,d15.Cisplatin (DDP) 20mg/d.d15,a course of treatment every 28 days,Eifficacy and toxicity were evaluated after two cycles(range:2~4).Results:The combined group and the radiotherapy alone group remission rates were 82.6% and 58.7% (P <0.05).Conclusion:The efficacy of chemotherapy(C) with DF combined with radiotherapy is superior to radiotherapy alone,toxicity can be tolerated,and may be a therapeutic alternative for esophageal cancer.