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车前子化学成分与药理作用研究进展及质量标志物预测分析
引用本文:李冲冲,龚苏晓,许浚,张笑敏,许姗姗,张慧娟,张铁军,刘昌孝.车前子化学成分与药理作用研究进展及质量标志物预测分析[J].中草药,2018,49(6):1233-1246.
作者姓名:李冲冲  龚苏晓  许浚  张笑敏  许姗姗  张慧娟  张铁军  刘昌孝
作者单位:天津中医药大学中药学院, 天津 300193,天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,天津中医药大学中药学院, 天津 300193;天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,天津中医药大学中药学院, 天津 300193;天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,天津药物研究院 天津市中药质量控制技术工程实验室, 天津 300193,释药技术与药物代谢动力学国家重点实验室, 天津药物研究院, 天津 300193
基金项目:国家中药标准化项目(ZYBZH-Y-JX-27);国家自然科学基金重点项目(81430096)
摘    要:车前子是我国传统的常用中药材,分布于全国各地,资源丰富。近年来国内外学者对车前子各方面研究逐渐深入,其有效成分及应用开发研究备受关注,具有广泛的应用前景。在对其化学成分及药理作用综述的基础上,根据质量标志物定义,从化学成分与传统药性、传统功效、临床新用途相关性、入血成分、可测成分、不同配伍中显效成分、贮藏时间影响等几个方面对车前子质量标志物成分进行预测分析,为车前子质量评价研究提供科学依据。

关 键 词:车前子  环烯醚萜类  苯乙醇苷  质量控制  质量标志物
收稿时间:2018/1/20 0:00:00

Research progress on chemical composition and pharmacological effects of Semen Plantaginis and predictive analysis on Q-marker
LI Chong-chong,GONG Su-xiao,XU Jun,ZHANG Xiao-min,XU Shan-shan,ZHANG Hui-juan,ZHANG Tie-jun and LIU Chang-xiao.Research progress on chemical composition and pharmacological effects of Semen Plantaginis and predictive analysis on Q-marker[J].Chinese Traditional and Herbal Drugs,2018,49(6):1233-1246.
Authors:LI Chong-chong  GONG Su-xiao  XU Jun  ZHANG Xiao-min  XU Shan-shan  ZHANG Hui-juan  ZHANG Tie-jun and LIU Chang-xiao
Affiliation:Tianjin University of Traditional Chinese Medicine, College of Chinese Medicine, Tianjin 300193, China,Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, College of Chinese Medicine, Tianjin 300193, China;Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, College of Chinese Medicine, Tianjin 300193, China;Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China and Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Abstract:Semen Plantaginis is a traditional Chinese herbal medicine, which widely distributed in various parts of China and the medicine source is rich. In recent years, domestic and overseas scholars have taken up in-depth research on the various aspects of Semen Plantaginis, and its effective ingredients and application development research has attracted much attention, and has broad application prospect. Based on the review of its chemical composition and pharmacological effects, according to the definition of Q-marker, the quality control component of Semen Plantaginis were predicted from the aspects of the correlation between chemical composition and traditional medicinal properties, traditional efficacy, and new clinical use, plasma composition, measurable composition, active ingredients in different compatibility, storage time and so on, which provides a scientific basis for quality evaluation of Semen Plantaginis.
Keywords:Semen Plantaginis  iridoids  phenylethanoid glycoside  quality control  quality marker (Q-marker)
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