| 伏康树中单萜吲哚类生物碱及其NMR波谱特征 |
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| 引用本文： | 陈红梅,邓赟,宋川霞,戴宇,胡佳,康敏,但小梅,李鸿翔.伏康树中单萜吲哚类生物碱及其NMR波谱特征[J].中国实验方剂学杂志,2015,21(7):216-222. |
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| 作者姓名： | 陈红梅 邓赟 宋川霞 戴宇 胡佳 康敏 但小梅 李鸿翔 |
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| 作者单位： | 成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137,成都中医药大学 药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 成都 611137 |
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| 基金项目： | 国家自然科学基金面上项目(81373961);国家"重大新药创制"科技重大专项(2014ZX09201021-008);四川省科技厅省青年科技创新研究团队专项计划项目(2014TD0007) |
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| 摘 要： | 伏康树中主要化学成分为生物碱类化合物。自1956年首次从非洲马铃果中分离得到老刺木灵至今,已从该植物中分离出多种吲哚类生物碱。该类生物碱在天然产物中生物活性优异而广泛,尤其是近年来研究发现其在抗肿瘤方面表现良好,因此对该类化合物进行研究具有重要意义。本文查阅国内外研究文献,将伏康树中分离得到的生物碱及NMR波谱特征进行归纳、总结。迄今已从伏康树中分离鉴定了69个生物碱,均为单萜吲哚类生物碱,其中单萜吲哚生物碱46个,双聚单萜吲哚生物碱23个。这些生物碱结构复杂,骨架类型丰富,但在结构上有一定规律,根据单萜部分结构变化对其结构进行分类,同时对各类型单萜吲哚类生物碱波谱规律进行总结,对进一步鉴定该类化合物结构以及进行波谱数据的归属都起着重要的作用。
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| 关 键 词： | 伏康树 吲哚类生物碱 波谱特征 结构类型 |
| 收稿时间： | 2014/5/13 0:00:00 |
Monoterpenoid Indole Alkaloids and Nuclear Magnetic Resonance Spectroscopy Characteristics in Voacanga africana |
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| CHEN Hong-mei,DENG Yun,SONG Chuan-xi,DAI Yu,HU Ji,KANG Min,DAN Xiao-mei and LI Hong-xiang.Monoterpenoid Indole Alkaloids and Nuclear Magnetic Resonance Spectroscopy Characteristics in Voacanga africana[J].China Journal of Experimental Traditional Medical Formulae,2015,21(7):216-222. |
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| Authors: | CHEN Hong-mei DENG Yun SONG Chuan-xi DAI Yu HU Ji KANG Min DAN Xiao-mei and LI Hong-xiang |
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| Affiliation: | College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China,College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China and College of Pharmaceutical, Chengdu University of Traditional Chinese Medicine, Key Laboratory Min-sity of Education of Chinese Medicine Standardization Lab, State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China |
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| Abstract: | Consulting related literatures at home and abroad, alkaloids isolated from Voacanga africana staph and the Nuclear Magnetic Resonance (NMR) Spectroscopy Characteristics were summarized. At present, 69 alkaloids have been isolated and identified, all are monoterpenoid indole alkaloids. 46 of them are monoterpenes indole alkaloids, and 23 of them are bis (monoterpenes) indole alkaloids. These alkaloids have complex skeletons, rich types, classify them according to the changes of monoterpene structure. Through summarizing the rules of spectroscopic characteristics about alkaloids from Voacanga africana staph, it plays an important role to identify structure and attribution spectral data of this type of compounds. |
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| Keywords: | Voacanga africana indole alkaloids spectroscopic characteristics structure types |
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