盐酸戊乙奎醚雾化吸入治疗慢性阻塞性肺疾病急性发作的疗效观察

目的:观察盐酸戊乙奎醚雾化吸入治疗慢性阻塞性肺疾病急性发作的疗效。方法:选择2008年6月～2010年8月在我科诊治的COPD急性发作患者108例。随机将其分为观察组和对照组各54例。2组患者均给予低流量吸氧、控制感染、解痉平喘、止咳化痰、纠正电解质及酸碱平衡紊乱等对症治疗;观察组使用盐酸戊乙奎醚雾化吸入;对照组使用喘定雾化吸入。结果:观察组总有效率为90.74%,明显高于对照组的总有效率75.93,经统计学处理,两组总有效率比较,差异有显著性(x~2=4.267,P<0.05)。两组患者治疗后用力肺活量(FVC)、1秒钟用力呼气容积(FEV1)及1秒钟用力呼气容积占用力肺活量百分比(FEV1/FVC%)明显优于治疗前,治疗前后比较差异有统计学意义P<0.05,或P<0.01);治疗后观察组FVC、FEV1、FEV1/FVC%改善情况与对照组比较差异均有统计学意义(P<0.05,或P<0.01);治疗后观察组动脉血气与对照组比较差异均有统计学意义P<0.05)。结论:在常规治疗基础上加用盐酸戊乙奎醚治疗COPD急性发作,可明显提高患者的疗效,缓解症状,显著改善患者的血气分析、肺功能的指标,值得临床推广。

Clinical Observation of Penehyclidine Hydrochloride Inhalationon the Acute Episode of Chronic Obstructive Pulmonary

Objective:To observe the effectiveness of penehyclidine hydrochloride inhalation on the acute episode of chronic obstructive pulmonary.Methods:108 patients with definite acute episode of COPD from June 2008 to August 2010 were treated and selected in our hospital.They were randomly assigned to two groups including observation group and control group,each of which had 54 cases.In two groups,all patients received symptomatic treatment such as low frequency inhalation,infectious control,spasmolysis and antiasthmatic treatment,relieving cough and reducing sputum,rectifying disturbance of electrolyte and acid-base balance.In observation group,the patients received penehyclidine hydrochloride inhalation,while in control group,the patients received diprophylline inhalation. Results:In observation group,the total effective rate was 90.74%,while it was 75,93%in control group.Besides,there was statistical significance between two groups(χ~2=4.267,P<0.05).The forced vital capacity(FVC),forced expiratory volume at one second(FEV1) and the ratio of forced expiratory volume to forced vital capacity(FEV1/FVC%) significantly surpassed those before treatment(P<0.05 or P<0.01).Furthermore,for the improvement of FVC,FEV1,FEV1/FVC%,there was statistical significance between two groups(P<0.05 or P<0.01).There was statistical significance for arterial blood gas between two groups after treatment(P<0.05).Conclusions:The penehyclidine hydrochloride combined with the conventional therapy can improve the acute episode of COPD,relieve the symptoms and evidently improve blood gas analysis or lung function and was worthy to be generalized.