吡喃阿霉素与阿霉素为主的方案治疗非何杰金淋巴瘤的临床对比观察

目的 :比较含吡喃阿霉素 (CTOP)和阿霉素 (CHOP)的方案治疗非何杰金淋巴瘤的疗效和毒副反应。方法 :2 4 1例非何杰金淋巴瘤病人分别接受CTOP和CHOP方案治疗 ,每 3周为一周期 ,最少治疗 3周期。结果 :CTOP组和CHOP组的完全缓解率分别为 4 6 .1% ,4 1.6 %。总有效率 (CR +PR)分别为 85 .9% ,81.4 %。两组的完全缓解率和总有效率经统计学分析 ,均无显著性差异 (P >0 .0 5 )。两组的骨髓、胃肠道、血液和心脏毒性 ,均无统计学上的差异。脱发发生率分别为 31.3%、70 .8% ,CTOP组明显低于CHOP组 ,两组有显著性差异。结论 :CTOP与CHOP相比 ,疗效相近 ,脱发反应较轻。远期疗效有待观察。

Comparative Study of Pirarubicin And Adriamyicin on the Treatment of Non- Hodgkin's Lymphoma

Objective:To compare the effects and toxicities of pirarubi cin-containing (CTOP)and adriamycin-containing(CHOP) combination chemotherapy on non-Hodgkin's lymphoma(NHL).Method:241 patients with NHL were treated with CTOP and CHOP respectively for more then 3 cycles,repeated every 3 weeks.Results:Com plete response rates of CTOP and CHOP were 46.1% and 41.6% respectively.Overall response rates were 85.9% and 81.4% respectively.There were no difference betwee n the two groups.There were no difference in gastrointestinal,hematologic and c ardiac toxicities between the two groups.Incidence of hair loss in two groups we re 31.4% and 70.8% respectively.There was a significant difference in hair loss between the two groups.Conclusion:The efficacy of CTOP on NHL is similar to tha t of CHOP.hair loss in CTOP is milder than CHOP.Long-term efficacy must be studied further.