孕妇血清抗心磷脂抗体水平与妊娠结局的关系

目的：阐述孕妇血清抗心磷脂抗体（ACA）水平与妊娠结局的关系。方法：采用ELISA测定309名妊娠晚期妇女的血清ACA－IgM、IgA、IgG综合指数，观察孕妇血清ACA水平与妊娠并发症，新生儿低出生体重及围产儿缺氧的关系。结果：妊娠并发症组、低出生体重组和围产儿缺氧组ACA结合指数的变化以IgM、IgA为主，与对照组比较，各组ACA－IgM、IgA结合指数均显著增高（P＜0．001－0．05）；妊娠并发症组ACA－IgG结合指数显著增高（P＜0．001），轻度和中、重度妊高征患者间ACA结合指数无显著性差异（P均＞0．05）；低体重儿组新生儿本重与ACA结合指数无显著相关性（P均＞0．1），1种并发症和2种并发症患者间比较，ACA－IgM、IgG无明显性差异（P＞0．1，P＞0．05，ACA－IgA有显著性差异（P＜0．001）。结论：孕妇血清ACA水平增高可能与妊娠并症、低出生体重、围产儿缺氧等不良妊娠结局的发生有关。

Relationship between Anticardiolipin Antibody in Gravida Serum and Pregnancy Outcomes

To study the relationship between anticardiolipin antibody (ACA) in gravida serum and pregnancy outcomes. Methods Binding indices of serum ACA-IgM, IgA and IgG were detected for 309 gravidas in third trimester by ELISA . The relationships between ACA in gravida serum and gestational complications, low birth weight of neonate, perinatal anoxia were analyzed respectively. Results The changes of ACA binding indices happened mainly on IgM and IgA in the groups of gestational complications, low birth weight of neonate and perinatal anoxia. The binding indices of ACA-IgM and IgA in these groups were significantly higher than the control group. The ACA-IgG binding indices increased significantly in the group with gestational complications. There was no significantly difference on the ACA binding indices between the groups with mild and moderate or severe gestational hypertension. The correlation was not significant between the neonate weight and ACA binding indices of the group of low birth weight ( P > 0.1). Comparing the patients with one kind of gestational complication and those with two kinds of gestational complications, no significant difference showed on ACA-IgM and IgG while significant difference showed on ACA-IgA. Conclusion The rise of ACA in gravida serum may be correlated with poor results of pregnancy, such as gestational complications, low birth weight and perinatal anoxia.