| 缺血性脑卒中病因学亚型的遗传学分析 |
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| 引用本文： | 高一鹭,王薇,张拥波,李继梅. 缺血性脑卒中病因学亚型的遗传学分析[J]. 中国全科医学, 2011, 14(29) |
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| 作者姓名： | 高一鹭 王薇 张拥波 李继梅 |
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| 作者单位： | 首都医科大学附属北京友谊医院神经内科,北京市,100050 |
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| 基金项目： | 北京市卫生系统高层次卫生技术人才培养计划项目资助 |
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| 摘 要： | 缺血性脑卒中(ischaemic stroke,IS)是一种与遗传因素密切相关的多基因疾病.本文将探讨与脂质代谢、炎症反应、血小板活化、同型半胱氨酸代谢等相关的IS候选基因,并分析IS不同病因学亚型易感基因多态性,以利于IS病因学诊断及个体化的治疗与预防.
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| 关 键 词： | 缺血性脑卒中 遗传学 多态性,单核苷酸 病因学亚型 |
Genetics Analysis of Etiological Subtypes of Ischaemic Stroke |
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| GAO Yi-lu,WANG Wei,ZHANG Yong-bo,et al.. Genetics Analysis of Etiological Subtypes of Ischaemic Stroke[J]. Chinese General Practice, 2011, 14(29) |
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| Authors: | GAO Yi-lu WANG Wei ZHANG Yong-bo et al. |
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| Affiliation: | GAO Yi-lu,WANG Wei,ZHANG Yong-bo,et al.Department of Neurology,Affiliated Beijing Firendship Hospital,Capital Medical University,Beijing 100050,China |
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| Abstract: | Ischemic stroke(IS) is a polygenic disease closely related to genetic factors.In this review,we discuss the candidate genes for IS involved in lipid metabolism,inflammation,platelet activation,homocysteine metabolism and so on.We also analyze the polymorphisms of the predisposing genes among different etiological subtypes of IS to facilitate the etiological diagnosis and individualized prevention of IS. |
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| Keywords: | Ischaemic stroke Genetics Polymorphism single nucleotide Etiological subtype |
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