子宫内膜癌组织雌激素及孕激素受体的测定及其临床意义

目的：探讨子宫内膜癌组织雌激素受体（ＥＲ）和孕激素受体（ＰＲ）与临床病理特征的关系。方法：用葡聚糖－活性碳吸附法（ＤＣＣ法）对７０例子宫内膜癌原发病灶组织进行ＥＲ及ＰＲ测定，同时用免疫组化法对其中３０例的石蜡标本进行了ＥＲ及ＰＲ的检测。结果：ＤＣＣ法检测ＥＲ及ＰＲ的阳性率均为７７．１％，免疫组化法均为８３．３％。两种测定方法比较，ＥＲ与ＰＲ的总符合率分别为８３．３％和８６．７％。而免疫组化法可在ＤＣＣ法基础上进一步明确组织来源。ＥＲ及ＰＲ水平与组织学分级呈负相关。组织类型中，腺癌（包括乳头状腺癌）与腺棘癌的ＥＲ及ＰＲ水平高于其它癌。ＥＲ水平与肥胖呈正相关。结论：ＥＲ及ＰＲ水平与组织学分级、组织学类型均反映了子宫内膜癌的生物学行为，ＥＲ及ＰＲ的测定对估计预后和临床选择内分泌治疗具有重要意义。

Estrogen and Progesterone Receptors in Endometrial Carcinoma

Objective: To study the relationship between estrogen receptor(ER) and progesterone receptor(PR) contents and the clinico pathologic features in endometrial carcinoma. Methods: ER and PR contents of fresh tumor tissues taken from 70 cases of primary endometrial carcinoma were measured by biochemical (DCC) method and 30 paraffin embedded archival specimens of the 70 cases also by immunohistochemical (IHC) method. Results: Both ER and PR positive rates were 77.1% by DCC assay and 83.3% by IHC method. Excellent correspondency of one method to the other was observed (ER 83.3%, PR 86.7%). And the IHC method displayed further the origin of the tissue examined. The ER and PR levels correlated negatively with the grades of tumor ( P <0.01). ER and PR positive rates in adenocarcinoma (including papillary adenocarcinoma) and adenoacanthoma were higher than those in the other histological types (ER, P <0.01; PR, P <0.005). There was a positive correlation between the ER levels and obesity. Conclusions: The levels of ER and PR and the histopathological classification and grading of the tumor tissue reflect biologic behaviors of endometrial carcinoma. ER and PR assays are important for endocrinotherapy and in predicting prognosis.