Treatment duration of wrist-ankle acupuncture for relieving post-thyroidectomy pain: A randomized controlled trial |
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| Affiliation: | 1. Department of Nursing, Chengdu Integrated TCM & Western Medicine Hospital, Sichuan 610041, Sichuan Province, China;2. School of Nursing, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China;3. Department of Nursing, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China;4. Department of General Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China;5. Department of Gynecology and Obstetrics, Guangzhou Women and Children’s Medical Center, Guangzhou 510120, Guangdong Province, China;1. State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology (Ministry of Education), School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China;2. Department of Clinical Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China;3. Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou 325000, Zhejiang Province, China;4. Yantai Fuheng Biological Technology Co., Ltd., Yantai 264006, Shandong Province, China;1. Traditional Chinese Medicine Epigenomics Research Center, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Department of Rheumatology and Immunology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing 211299, Jiangsu Province, China;3. Department of Rheumatology and Immunology, Yangzhou University Medical College, Yangzhou 225000, Jiangsu Province, China;4. Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa 761-0793, Japan;5. Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;1. SDG 03 Group–Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria;2. Department of Biochemistry, Landmark University, Omu-Aran 251101, Kwara State, Nigeria;3. Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo 232101, Osun State, Nigeria |
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| Abstract: | BackgroundTreatment duration of wrist-ankle acupuncture (WAA) is uncertain for post-thyroidectomy pain relief.ObjectiveThis study evaluated the effect of different WAA treatment duration on post-operative pain relief and other discomforts associated with thyroidectomy.Design, setting, participants and interventionThis randomized controlled trial was conducted at a single research site in Guangzhou, China. A total of 132 patients receiving thyroidectomy were randomly divided into the control group (sham WAA, 30 min) and three intervention groups (group 1: WAA, 30 min; group 2: WAA, 45 min; group 3: WAA, 60 min), with group allocation ratio of 1:1:1:1. Acupuncture was administered within 1 hour of leaving the operating room.Outcomes and measuresPrimary outcome was patients’ pain at the surgical site assessed by visual analogue scale (VAS) at the moment after acupuncture treatment (post-intervention). Secondary outcomes included the patients’ pain VAS scores at 6, 12, 24, 48 and 72 h after the thyroidectomy, the 40-item Quality of Recovery (QoR-40) score, the grade of post-operative nausea and vomiting (PONV), and the use of additional analgesic therapy.ResultsThe adjusted mean difference (AMD) in VAS scores from baseline to post-intervention in group 1 was −0.89 (95% confidence interval CI], −1.02 to −0.76). The decrease in VAS score at post-intervention was statistically significant in group 1 compared to the control group (AMD, −0.43; 95% CI, −0.58 to −0.28; P < 0.001), and in groups 2 and 3 compared to group 1 (group 2 vs group 1: AMD, −0.65; 95% CI, −0.81 to −0.48; P < 0.001; group 3 vs group 1: AMD, −0.66; 95% CI, −0.86 to −0.47; P < 0.001). The VAS scores in the four groups converged beyond 24 h after the operation. Fewer patients in group 2 and group 3 experienced PONV in the first 24 h after operation. No statistical differences were measured in QoR-40 score and the number of patients with additional analgesic therapy.ConclusionCompared with the 30 min intervention, WAA treatment with longer needle retention time (45 or 60 min) had an advantage in pain relief within 6 h after surgery. WAA’s analgesic effect lasted for 6–12 h post-operatively.Please cite this article as: Han XR, Yue W, Chen HC, He W, Luo JH, Chen SX, Liu N, Yang M. Treatment duration of wrist-ankle acupuncture for relieving post-thyroidectomy pain: A randomized controlled trial. J Integr Med. 2023; 21(2): 168–175. |
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| Keywords: | Thyroidectomy Thyroid tumor Wrist-ankle acupuncture Post-operative pain Randomized controlled trial |
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