男性冠状动脉慢血流和红细胞压积的相关性研究

目的 探讨男性冠状动脉慢血流（SCF）与红细胞压积的相关性。 方法 以北京安贞医院心内科2011年8月至2012年8月经造影证实冠状动脉狭窄〈40%的205例男性患者为研究对象，其中101例红细胞压积〉42.9%者作为研究组，104例红细胞压积≤42.9%作为对照组，比较两组临床变量。 结果 研究组年龄低于对照组，而白细胞计数、血小板平均体积、三酰甘油、低密度脂蛋白胆固醇、前降支动脉TIMI帧数、右冠状动脉TIMI帧数及前降支动脉SCF比例均高于对照组（P〈0.05）。相关分析结果提示，前降支动脉TIMI帧数（r=0.238，P=0.001）、前降支动脉SCF比例（r=0.206，P=0.003）和右冠状动脉TIMI帧数（r=0.209，P=0.003）与红细胞压积正相关。Logistic回归分析校正年龄等因素后提示，前降支动脉TIMI帧数［OR=1.031，95%CI（1.006，1.056），P=0.014］、前降支动脉SCF的比例［OR=1.919，95%CI（1.038，3.547），P=0.038］与红细胞压积独立相关。 结论 男性前降支动脉SCF与红细胞压积独立相关，高水平红细胞压积可能促进了SCF的发生发展。

Correlation between Hematocrit and Slow Coronary Flow in Male Patients

Objective To explore the correlation between hematocrit and slow coronary flow （SCF） in male patients.
Methods We studied 205 patients with angiographically no more than one stenosis 〈40% in each major coronary artery who had admitted to the department of cardiology of the Beijing Anzhen Hospital Affiliated to Capital Medical University from August 2011 to August 2012. According to the level of hematocrit, 101 patients were classified into the trial group whose hematocrit was more 42.9%, while 104 patients into the control group whose hematocrit was no more than 42.9%. Clinical variables were analyzed and compared between the two groups.
Results The age was younger in the trial group than the control group, whereas the levels of white blood cell count, mean platelet volume, triglyceride, low-density lipoprotein cholesterol, left anterior descending artery （LAD） and right coronary artery （RCA） TIMI frame count and the proportion of SCF in the LAD were higher in the trial group than in the control group （P〈0.05）. The results of correlation analysis showed that, LAD TIMI frame count （r=0.238, P=0.001）, proportion of SCF in the LAD （r=0.206, P=0.003） and RCA TIMI frame count （r=0.209, P=0.003） were positively correlated with hematocrit. The results of multivariate analysis （using logistic regression with adjusted confounding factors such as age） showed that, LAD TIMI frame count （OR=1.031, 95%CI 1.006 to 1.056, P=0.014）, proportion of SCF in the LAD （OR=1.919, 95%CI 1.038 to 3.547, P=0.038） were independently correlated with hematocrit.
Conclusion The proportion of SCF in the LAD is independently correlated to hematocrit, which suggested that increased hematocrit may contribute to the pathophysiological change of SCF in male patients.