Chronic myelogenous leukemia in the monosomic cell line of a fertile turner syndrome mosaic (45,X/46,XX) |
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Authors: | RSK Chaganti Roller B Bailey Suresh C Jhanwar Zalmen A Arlin Bayard D Clarkson |
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Affiliation: | 1. Laboratory of Cancer Genetics and Cytogenetics, Memorial Sloan-Kettering Cancer Center, New York, USA;2. Hematology and Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, USA |
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Abstract: | Malignancy in patients with constitutional chromosome abnormality is of interest not only because it permits insights into the relationship between chromosome abnormality and cancer, but also because it provides opportunities to address such questions as the clonality and evolution of tumors. We report Ph1-positive chronic myelogenous leukemia (CML) in a 50-year-old mosaic (45,X/46,XX) Turner syndrome patient whose leukemia was restricted to the monosomic cell line. Our extensive cytogenetic studies of this patient demonstrated that non-leukemic normal cells persisted in the marrow and were able to proliferate during a period of temporary suppression of the leukemic clone following aggressive treatment. |
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Keywords: | Address requests for reprints to Dr R S K Chaganti Laboratory of Cancer Genetics and Cytogenetics Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10017 |
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