加用三金片治疗小儿急性肾小球肾炎的临床研究

目的 :观察加用三金片对小儿急性肾小球肾炎的治疗作用。方法 :在临床上 ,加用三金片治疗小儿急性肾小球肾炎 4 0例 (观察组 ) ,并与西药组 38例及正常对照组 4 0例对比。结果 :急性肾小球肾炎患者 (包括观察组及西药组 )脂质过氧化物 (LPO)、谷胱苷肽过氧化物酶 (GSH -Px)与正常组比较有显著性差异 (P <0 .0 0 1 ) ,而超氧化物岐化酶 (SOD)则无显著性差异 (P >0 .0 5)。经治疗后LPO降低 ,GSH -Px增高 ,观察组疗效优于西药组 (P <0 .0 5)。患儿前列腺素稳定代谢产物 6-K -PGF1a降低 ,TXB2 下降 ,TXB2 /6-K -PGF1a比值升高 ,与正常组相比具有显著差异 (P <0 .0 0 1 )。治疗后TXB2 下降 ,6-K -PGF1a升高 ,TXB2 /6-K -PGF1a下降 ,观察组疗效优于西药组 (P <0 .0 1 )。此外 ,观察组患儿血尿和蛋白尿阳转率也明显优于西药组。结论 :提示观察组用药具有较强的抗自由基及消除炎性致病因子能力 ,并且对肾功能有良好的保护作用

Clinical Study on the Treatment of Infantile Acute Glomerulonephritis with Additional Application of San Jinpian

Purpose: To observe the curative effect of the additional use of San Jinpian on infantile acute glomerulonephritis(IAG). Methods: Clinically, 40 cases with IAG ( the control group) were treated with the additional use of San Jinpian to compare its effect with 38 cases treated with only western medicine(WM group) and with 40 cases in the control group. Results: When compared with the control group, the observation group and WM group showed a significant difference in LPO and GSH-Px( P<0.001), while there was no significant difference in SOD(P< 0.05 ). After the treatment, LPO became lower but GSH-Px increased, with the observation group achieving better curative effects than WM group (p<0.05) 6-K-PGF 1a and TXB 2 became lower and the ratio of TXB 2 to 6-K-PGF 1a was increased with a very significant difference between the observation group and the control group (P<0.001) . After the treatment, TXB 2 became lower while 6-K-PGF 1a higher and the ratio of TXB 2 to 6-K-PGF 1a was lower, with the better effect shown in the observation group than in WM group (P<0.01). In addition, the transitional rate of hematuria and proteinuria from positive to negative was better in the observation group than in the WM group. Conclusions: It is suggested that San Jinpian added to the observation group has a considerably strong ability to resist free radicals. It can also remove inflammatory pathogenic factors and protect renal functions.