血清CA19-9检测对胆胰疾病的诊断价值

目的 探讨血清肿瘤标记物CA19-9检测对胆胰疾病的诊断价值.方法 229例胆胰疾病患者,分为恶性肿瘤组、胆石症组、胆囊良性占位组、急慢性胆囊炎组、胆总管囊肿组,其中恶性肿瘤组、胆石症组进一步分为黄疸组和无黄疸组,采用电化学方法及生化比色法检测上述患者血清CA19-9和总胆红素水平.结果 ①恶性肿瘤组各组血清CA19-9水平明显高于胆石症无黄疸组、胆囊良性占位组、急慢性胆囊炎组、胆总管囊肿组,差异有统计学意义(P＜0.05),但恶性肿瘤各组与胆石症黄疸组血清CA19-9水平接近,差异无统计学意义(P＞0.05).②胆石症黄疸组血清CA19-9水平与总胆红素水平之间呈正相关(r=0.5874,P＜0.05),而其余各组,两者之间无直线相关关系(P＞0.05).结论 血清CA19-9的检测可用于胆胰恶性肿瘤的筛查,但对于血清CA19-9升高同时合并阻塞性黄疸的患者需进一步结合其他辅助检查方能鉴别阻塞性黄疸的良恶性.

The diagnostic value of detection serum carbohydrate antigen 19-9 for biliary and pancreatic diseases

Objective To explore the diagnostic value of detection serum carbohydrate antigen 19-9(CA19-9)for biliary and pancreatic diseases.Methods 229 patients suffering from biliary and pancreatic diseases were divided into five groups:tumor group,cholelithiasis group,benign mass of gallbladder group,acute or chronic cholecystitis group,choledochal cyst group,then tumor and cholelithiasis groups were divided into two groups:obstructive and nonobstructive jaundice group.These patients were detected the serum CA19-9 and total bilirubin level by electrochemical method and biochemical colorimetric method.Results①The level of serum CA19-9 was higher in tumor group than cholelithiasis group with nonobstructive jaundice,benign mass of gallbladder group,acute or chronic cholecystitis group,choledochal cyst group(P<0.05),the serum CA19-9 level had no statistically difference between tumors and cholelithiasis group with obstructive group(P>0.05).②The increase of serum CA19-9 was positively correlated with increase of serum total bilirubin(r=0.5876,P<0.05),however,there was no correlation in other groups(P>0.05).Conclusion Dection of serum CA19-9 can be used for screening of malignant tumors of biliary and pancreatic.But the patients with serum CA19-9 rise and obstructive jaundice need to be further identify benign and maligant of obstructive jaundice in combination with other auxiliary examination method.