| 环孢素A肾中毒时大鼠尿中前列腺素的变化 |
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| 引用本文： | 李民,李俊卿.环孢素A肾中毒时大鼠尿中前列腺素的变化[J].河南医学研究,1996,5(3):236-239. |
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| 作者姓名： | 李民 李俊卿 |
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| 作者单位： | 河南医科大学第二附属医院泌尿外科，河南医科大学第二附属医院检验科 |
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| 摘 要： | 该实验探讨了环孢素Ａ（ＣｓＡ）肾中毒与肾脏血栓素Ａ２（ＴＸＡ＿２）、前列环素（ＰＧＩ＿２）的关系。实验中将ＳＤ雄性大鼠２０只随机分为二组，Ｉ组为正常对照组；Ⅱ组为ＣｓＡ中毒组。于实验前后分别检测大鼠的肾功能、尿酶以及尿中血栓素Ｂ＿２（ＴＸＢ＿２）、６－酮－前列腺素Ｆ１ａ（６－ｋｅｔｏ－ｐＧＦ１ａ）等指标，最后进行肾脏光镜检查。结果发现，ＣｓＡ中毒组大鼠尿中的ＴＸＢ＿２显著升高，而尿中６－ｋｅｔｏ－ｐＧＦ１ａ稍低于正常对照组，ＴＸＢ＿２／６－ｋｅｔｏ－ｐＧＦ１ａ比值明显升高。实验证实，中毒剂量的ＣｓＡ引起肾脏ＴＸＡ＿２／ＰＧＩ＿２平衡常数明显升高。
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| 关 键 词： | 环孢素A肾中毒，血栓素A＿2，前列环素 |
THE CHANGE OF URINARY PROSTAGLANDIN CONTENTS IN RATS WITH NEPHROTOXICITY INDUCED BY CYCLOSPORIN E A |
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| Li Min,LiJun-qing,Zhao Yue-cun.THE CHANGE OF URINARY PROSTAGLANDIN CONTENTS IN RATS WITH NEPHROTOXICITY INDUCED BY CYCLOSPORIN E A[J].Henan Medical Research,1996,5(3):236-239. |
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| Authors: | Li Min LiJun-qing Zhao Yue-cun |
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| Abstract: | This study is designed to investigate effect of Cyclosporine A(CsA)nephro-toxicity on urinary thromboxane A2 and prostacyclin,Male Sprague-Dawley rats were dividedinto two groups. Group I is as control;group Ⅱ,rats received a daily oral dose of CsA(50mg/kg)by gavage for seven days,Before and on day 7 of treatment,rat renal function,urinary enzyme and urinary thromboxane B2(TXB2)and 6-keto-prostaglandin F1a(6-keto-PGF1a)were measured.On day 7,kidneys were examined under light lnicroscope.The resultsindicated that CsA produced an acute impairment of renal function,and concomitantly in-creased the ratio of urinarv TXB2/6-keto-pGF1a |
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| Keywords: | cyclosporine A nephrotoxicity thromboxane A2 prostacyclin |
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