美沙西汀-甲氧基-13C及其类似物的合成

美沙西汀-甲氧基-¹³C是一种最具潜力的标记底物，用于呼气检测肝功能。本研究以甲醇-¹³C为标记原料，通过Mitsunobu反应、官能团修饰高效合成了美沙西汀-甲氧基-¹³C，合成收率为63%，产品纯度＞99%。同时应用该方法以甲醇-¹³C为标记原料合成了对甲氧基苯甲酸-甲氧基-¹³C，合成收率为67%，产品纯度＞99%。建立的合成美沙西汀-甲氧基-¹³C的新方法可为呼气检测肝功能研究的开展提供参考。

Synthesis of Methacetin-Methoxy-13C and its Analogue

In the current research on ¹³C-labeled compounds breath test of liver function, methacetin-methoxy-¹³C is the most potential substrate. To study a new method for synthesis methacetin-methoxy-¹³C, methanol-¹³C was used as the labeled material, methacetin-methoxy-¹³C was synthesized efficiently through Mitsunobu reaction and functional group modification. The synthesis yield was 63% and the chemical purity was above 99%. At the same time, this method was used to synthesize 4-methoxybenzoic acid-methoxy-¹³C with methanol-¹³C as the labeled material. The synthesis yield was 67% and the chemical purity was above 99%. The new scheme for the synthesis of methacetin-methoxy-¹³C with Mitsunobu reaction as the key reaction could provide a basis for the study of liver function by breath test.