| 体外培养经皮移植自体骨髓间充质干细胞治疗四肢骨不连 |
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| 引用本文： | 邹海兵,禹志宏,王家宁,丁元洪,郭晓鹏,孙志波.体外培养经皮移植自体骨髓间充质干细胞治疗四肢骨不连[J].郧阳医学院学报,2009,28(5). |
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| 作者姓名： | 邹海兵 禹志宏 王家宁 丁元洪 郭晓鹏 孙志波 |
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| 作者单位： | 邹海兵,禹志宏,丁元洪,郭晓鹏,孙志波(郧阳医学院附属人民医院,创伤骨科,湖北,十堰442000);王家宁(临床医学研究所,湖北,十堰442000) |
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| 基金项目： | 湖北省教育厅重点项目 |
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| 摘 要： | 目的:探讨体外培养经皮移植自体骨髓间充质干细胞(MSCs)治疗四肢骨折骨不连的效果。方法:12例四肢骨折骨不连患者采用体外培养经皮移植自体MSCs治疗。结果:9例获得了骨性愈合,骨折愈合平均时间为5个月(4~7月),X线显示骨折线消失,骨痂形成。骨折愈合率为75%(9/12)。结论:体外培养经皮移植自体MSCs治疗四肢骨折骨不连创伤小、安全、并发症少,临床效果满意。
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| 关 键 词： | 移植 自体 骨髓间充质干细胞 骨不连 |
Percutaneous Transplantation of Autologous Marrow Mesenchymal Stem Cells Cultured in Vitro for Bone Nonunion Treatment |
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| Affiliation: | ZOU Hai-bing[1] YU Zhi-hong[1] WANG Jia-ning[2] DING Yuan-hong[1] GUO Xiao-peng[1] SUN Zhi-bo[1] |
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| Abstract: | Objective To explore the efficiacy of percutaneous transplantation with autologous marrow mesenchymal stem cells cultured in vitro on the treatment of bone nonunion.Methods Twelve patients with bone nonunion were treated by percutaneous transplantation of autologous mesenchymal stem cells cultured in vitro.Results The rate of fracture union was 75%(9/12),the average fracture union time was 5 months(4~7 months),X-ray demonstrated that the fracture line nearly disappeared and porosis increased.Conclusion Percutaneous transplantation of autologous marrow mesenchymal stem cells cultured in vitro for treatment of bone nonunion may be a less traumatic,safe,less complication and excellent clinical outcomes method. |
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| Keywords: | Transplantation Autologous Marrow mesenchymal stem cells Bone nonunion |
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