急性低氧时静注葡萄糖-胰岛素-钾溶液对心血管功能的影响

本文比较了麻醉狗在急性低氧时,少量静注葡萄糖-胰岛素-钾溶液(N=8)和生理盐水(N=6)对心血管功能的影响。动物吸入低氧混合气体共30分钟。于吸入后10分钟,PaO_2为低氧吸入前的29～31％,总外周血管阻力为低百吸入前的64～67％,肺动脉压升高43～49％。然后动物分别静注GIK和NS,并持续低氧吸入20分钟。静注GIK后5分钟,平均动脉压、心输出量、心搏量、心搏作功及左室内压均显著增加,但持续时间短暂;而静注NS组与则无显著变化。结果提示:急性低氧时,GIK一次小量静注可迅速显著改善心血管功能。

Effect of Intravenous Glucose-Insulin-Potassium on Cardiovascular Functions during Acute Hypoxia

The effect of intravenous infusion of glucose-insulin-potassium (G1K) on the cardiovascular functions during acute hypoxia was studied and was compared with that of normal saline(NS). 14 anesthetized dogs were forced to inhale a hypoxic gas mixture. After the first ten-minute inhalation, Pao2 and total peripheral vascular resistance decreased to 29~3l% and 66-67% of the pre-in-halation levels respectively while the pulmonary arterial pressure increased 43-49%. Then a bolus injection of GIK was given to 8 dogs, and an injection of NS to 6 dogs. Hypoxic gas inhalation was continued for 20 more minutes. 5 -10 minutes after GIK injection, the mean arterial pressure, cardiac output, stroke volume, stroke work , and left ventricular pressure all significantly increased, however, no apparent changes could be observed in any of the above mentioned parameters after NS injection. This result reveals that cardiovascular functions during acute hypoxia can be rapidly, markedly but temporarily improved when a small volume of GIK is administered intravenously.