清开灵软胶囊治疗急性上呼吸道感染的临床研究

目的:探讨清开灵软胶囊对急性发热的疗效,及其证效关系。方法:清开灵软胶囊采用每日4次,每次1.6 g的剂量口服,并以双黄连口服液做对照,观察急性上呼吸道感染发热患者129例,疗程3 d。结果:清开灵软胶囊愈显率73.34%,双黄连口服液愈显率43.59%,前者疗效优于后者(P<0.05)。清开灵软胶囊对风热型的疗效优于风寒型(P<0.05)。清开灵软胶囊降低体温和减少数脉、增加缓脉的作用较双黄连口服液显著(P<0.05)。清开灵软胶囊服用中,少数出现轻度胃肠道反应。结论:清开灵软胶囊是治疗急性上呼吸道感染发热疗效显著且副作用小的药品。

Clinical research of Qingkailing soft capsules in treating acute upper respiratory infection

Objective: To discuss the efficacy of Qingkailing soft capsules in treating acute fever,and the relationship between symptoms-effect and time effect.Method: Qingkailing soft capsules was taken orally,4 times a day,1.6 g each time.Shuanghuanglian kou fu liquid was taken as control.129 patients with acute upper respiratory tract infection were recruited.Result: There were 73.34% of patients cured by Qingkailing soft capsules and 43.59% cured by Shuanghuanglian kou fu liquid.The efficacy of the former was better than that of the latter(P<0.05).The efficacy of Qingkailing soft capsules in treating Fengrexing was better than that in Fenghanxing(P<0.05).The efficacy of Qingkailing soft capsules in reducing rapid pulse and adding moderate pulse was more remarkable than Shuanghuanglian kou fu liquid((P<0.05)).Taking Qingkailing soft capsules seldom induced mild gastrointestinal disturbance.Conclusion: Qingkailing soft capsules showed good result in the treatment of acute upper respiratory tract infection with less adverse effect.