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Assessing Particle Formation of Biotherapeutics in Biological Fluids

Authors:	Joachim Schuster Christine E Probst Hanns-Christian Mahler Susanne Joerg Joerg Huwyler Roman Mathaes

Affiliation:	1. Lonza Pharma and Biotech, Drug Product Services, Basel, Switzerland;2. Division of Pharmaceutical Technology, University of Basel, Pharmacenter, Basel, Switzerland;3. Luminex Corporation, Seattle, WA, USA

Abstract:

Keywords:	Protein aggregation Serum Subvisible particles Antibody stability AF"} {"#name":"keyword" "$":{"id":"kwrd0040"} "$$":[{"#name":"text" "_":"Alexa Fluor 488 BF"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"brightfield FIL"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"flow imaging IFC"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"imaging flow cytometry LO"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"light obscuration mAbs"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"monoclonal antibodies PBS"} {"#name":"keyword" "$":{"id":"kwrd0100"} "$$":[{"#name":"text" "_":"phosphate-buffered saline SbVP"} {"#name":"keyword" "$":{"id":"kwrd0110"} "$$":[{"#name":"text" "_":"subvisible particle SSC"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"side scatter
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