骨桥蛋白在卵巢肿瘤组织中的表达及其临床意义

 目的 探讨骨桥蛋白（osteopontin, OPN）在卵巢恶性肿瘤组织中的表达及其与临床病理特征的关系。 方法 采用免疫组化方法检测OPN在54例卵巢恶性肿瘤组织，20例交界性卵巢肿瘤组织，20例良性卵巢肿瘤组织和10例正常卵巢组织中的表达。 结果 OPN在恶性卵巢肿瘤组织中的阳性表达率为77.80％，显著高于交界性卵巢肿瘤的35％和良性卵巢肿瘤的15％，差异有统计 学意义（P<0.01）。OPN在正常卵巢组织中无表达。OPN在Ⅲ～Ⅳ期卵巢肿瘤组织中的表达明显高于Ⅰ～Ⅱ期（P＝0.029）；在有卵巢外转移组中的表达明显高于无转移组（P＝0.019）。OPN表达阳性组患者的累积生存率明显低于OPN阴性组（P＝0.038）。OPN表达是患者生存时间的独立影响因素。 结论 OPN在卵巢恶性肿瘤的发生、发展、浸润、转移中起重要作用。OPN的表达可作为判断卵巢恶性肿瘤患者预后的指标之一。

Expression and Clinical Significance of Osteopontin in Ovarian Tumor

Objective To investigate the expression of osteopontin(OPN) and its clinicopathological significance in ovarian tumors. Methods The expression of OPN was detected by immunohistochemistry method. In 54 cases of ovarian malignant tumor tissues, 20 cases of ovarian borderline tumor tissues, 20 cases of ovarian benign tumor tissues and 10 cases of normal ovarian tissues. Results The positive expression rate of OPN was 77.80% in ovarian malignant tumors, much higher than ovarian borderline tumors（35％）and ovarian benign tumors（15%）,（P<0.01）. There was no OPN expression in normal ovarian tissues. The positive rate of OPN expression was dramatically higher in stage Ⅲ～Ⅳ tumor tissues than that in stageⅠ～Ⅱ ones（P＝0.029）.The expression of OPN was also significantly higher in the patients with out metastasis than that in the patients with no metastasis (P＝0.019). The overall survival of the patients with OPN positive expression was significantly shorter than that of the negative ones（P＝0.038）. OPN expression was independent factor to decrease overall survival. Conclusion Overexpression of OPN may play an important role in the malignant transformation,development,invasion and metastasis of ovarian cancer. It has a potential clinical significance as a prognostic marker in ovarian cancer patients.