P120ctn在ER、PR阴性乳腺癌中的表达及其意义

目的:检测雌激素受体(ER)、孕激素受体(PR)阴性乳腺癌组织中连环蛋白P120(P120ctn)的表达,分析其与临床病理因素的关系。方法:采用免疫组织化学染色的方法对比分析了52例ER、PR阴性乳腺癌组织和23例癌旁正常乳腺组织及21例乳腺纤维腺瘤组织中P120ctn的表达。结果:52例ER、PR阴性乳腺癌组织中有32例P120ctn(61.53%)膜表达弱阳性或阴性表达,29例(52.76%)胞质表达阳性,总异常表达35例(67.30%)。21例乳腺纤维腺瘤组织中膜表达弱阳性6例(28.57%),胞质无表达。23例癌旁正常乳腺组织仅有2例为膜表达弱阳性(8.69%),其余均为胞膜正常表达。三者比较差异有显著性。29例组织分级Ⅰ～Ⅱ和23例组织分级Ⅲ中P120ctn的异常表达率分别为48.27% vs 78.26%(P<0.05);30例有淋巴结转移和22例无淋巴结转移的癌组织P120ctn的异常表达率分别为76.66% vs 40.90%(P<0.05);17例临床分期Ⅰ～Ⅱ和35例临床分期Ⅲ～Ⅳ组织中P120ctn的异常表达率分别为58.82% vs 65.71%(P>0.05)。P120ctn的异常表达与ER、PR阴性乳腺癌的组织学分级、淋巴结转移密切相关(P<0.05),与临床分期无关(P>0.05)。结论:P120ctn在ER、PR阴性乳腺癌的异常表达明显,可作为评估预后的一项有价值指标。

Expression and significance of P120ctn in ER and PR negative breast carcinoma tissues

Objective To investigate in vivo expression of P120ctn in breast carcinoma with ER、PR negative and analyze its relationship with pathological characteristics.Methods Immunohistochemical method was performed to detect expression of P120ctn in tissues from 52 cases of breast carcinoma with ER、PR negative,23 with normal breast tissues beside carcinoma and 21 breast adenofibroma.Results Of 52 cases of breast carcinoma with ER、 PR negative,reduced membranous expression of P120ctn was seen in 32 cases(61.53%) but cytoplasmic expression in 29(52.76%),with a total abnormal expression rate of 67.30%(35/52).Of 21 cases with breast adenofibroma,6 cases(28.57%) had decreased expression of P120ctn and none with cytoplasmic expression.Of 23 cases with normal breast tissues beside carcinoma reduced membranous expression of P120ctn was seen only in 2 cases.29 cases of organization classification Ⅰ ～ Ⅱ and 23 cases organization classification in Ⅲ P120ctn abnormalities expression rate 48.27% vs 78.26% respectively.30 cases had lymph node metastasis and 22 cases without lymph node metastasis of cancer tissue P120ctn abnormalities expression rate 76.66% vs 40.90% respectively Abnormal expression of P120ctn with ER、PR negative breast carcinoma was closely associated with histological grade and lymph node metastasis(P < 0.05),but not related with clinical stages(P > 0.05).Conclusions There was a high rate of abnormal expression of P120ctn in ER、PR negative breast carcinoma.P120ctn can be used as a valuable index for predicting prognosis condition of ER、PR negative breast carcinoma.