Ezrin蛋白在子宫内膜异位症中的表达及意义

目的 研究细胞骨架相关蛋白ezrin在子宫内膜异位症（endometriosis,EM）患者中的表达情况,探讨ezrin蛋白在EM发生、发展中的作用.方法 选择卵巢EM患者异位内膜标本60例作为异位内膜组,其在位内膜标本30例作为在位内膜组;正常子宫内膜20例作为正常内膜组,应用免疫组化EnvisionTM二步法检测ezrin蛋白在卵巢EM异位内膜、在位内膜和正常内膜的表达情况.结果 在位内膜组ezrin表达值高于正常内膜组,异位内膜组ezrin表达高于在位内膜组,在位内膜组及异位内膜重度组ezrin表达水平高于轻度组,差异均有统计学意义（均P＜0.05）.结论 ezrin蛋白可能在EM的发病机制中起着重要作用,ezrin蛋白的表达水平和EM的临床分期密切相关,提示ezrin可能在EM的发生、发展中起重要作用.

Expression of ezrin in endometriosis and its clinicopathological significance

Objective To investigate the expression of ezrin in endometriosis and its clinicopathological significance. Methods Ninety specimens from patients with endometriosis, including 60 specimens of ovarian endometriosis and 30 specimens of eutopic endometrium were collected; and 20 specimens of normal endometrium served as a controls. The expression of ezrin in ectopic and eutopic endometrium of endometriosis and in normal endometrium was detected by immunohistochemistry EnvisionTM method. Results Immunohistochemistry showed that the expression of ezrin in eutopic from women with endometriosis was higher than that in normal endometrium. The expression of ezrin in ectopic was higher than that in eutopic endometrium of endometriosis. The levels of ezrin expression in ectopic and eutopic endometrium from woman with severe endometriosis were much higher than those with mild endometriosis （all P〈0.05）. Conclusion The expression levels of ezrin were significantly correlated with the clinical stage of endometriosis, which suggests that ezrin might play an important role in development of endometriosis.