Survey for late-onset hypogonadism among old and middle-aged males in Shanghai communities |
| |
Authors: | Sun Kai Liang Guo-Qing Chen Xiang-Feng Ping Ping Yao Wen-Liang Zhang Shi-Jun Wang Bo Sun Ying-Hao Li Zheng |
| |
Affiliation: | Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. |
| |
Abstract: | This study sought to investigate late-onset hypogonadism (LOH) in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms (AMS) scale and androgen deficiency in aging males (ADAM) questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors (total testosterone (TT), free testosterone (fT), sex hormone-binding globulin (SHBG) and bioavailability of testosterone (Bio-T)). There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results: TT was not related to aging (P>0.05); levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level. |
| |
Keywords: | ADAM AMS late-onset of hypogonadism male aging old and middle-aged males survey |
本文献已被 PubMed 等数据库收录! |
|