| 芬氟拉明合用电针对大鼠脑内中央灰质单胺类释放的影响 |
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| 引用本文： | 李晓艳,朱崇斌,陈海南,朱燕华,吴根诚,许绍芬.芬氟拉明合用电针对大鼠脑内中央灰质单胺类释放的影响[J].中国药理学报(英文版),1999(7). |
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| 作者姓名： | 李晓艳 朱崇斌 陈海南 朱燕华 吴根诚 许绍芬 |
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| 作者单位： | 上海医科大学神经生物学教研室医学神生物学国家重点实验室，上海医科大学神经生物学教研室医学神生物学国家重点实验室，上海医科大学神经生物学教研室医学神生物学国家重点实验室，上海医科大学神经生物学教研室医学神生物学国家重点实验室，上海医科大学神经生物学教研室医学神生物学国家重点实验室，上海医科大学神经生物学教研室医学神生物学国家重点实验室 上海 中国 200032，上海 中国 200032，上海 中国 200032，上海 中国 200032，上海 中国 200032，上海 中国 200032 |
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| 基金项目： | Project supported by the National Natural Science Foundation of China, № 39670901，by Shanghai Municipal Health Bureau,№ 95(A)1117. |
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| 摘 要： | 目的:研究5-羟色胺释放剂芬氟拉明加强针刺镇痛前后大鼠脑内中央灰质(PAG)腹侧部单胺类递质的变化。方法:运用微透析及高效液相电化学检测方法。结果:电针后Nor的释放减少,而5-HT,5-HIAA和DA,HVA在AG部位含量升高(P<0.05,vs NS组)。当芬氟拉明合用电针时,5-HT,5-HIAA含量进一步升高,但Nor,DA及其代谢产物却无明显变化(P<0.05 vs NS EA组)。结论:电针能促进DA和5-HT释放但抑制Nor释放。芬氟拉明合用电针能进一步加强5-HT的释放。芬氟拉明加强针刺镇痛可能与进一步激活5-羟色胺系统有关。
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| 关 键 词： | 芬氟拉明 生物单胺类 电针 微透析 高压液相色谱法 电化学 水管周灰质 |
Effects of fenfluramine combined with electroacupuncture on monoamine release in periaqueductal gray of rat brain |
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| LI Xiao-Yan,ZHU Chong-Bin,CHEN Hai-Nan,ZHU Yan-Hua,WU Gen-Cheng,XU Shao-Fen.Effects of fenfluramine combined with electroacupuncture on monoamine release in periaqueductal gray of rat brain[J].Acta Pharmacologica Sinica,1999(7). |
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| Authors: | LI Xiao-Yan ZHU Chong-Bin CHEN Hai-Nan ZHU Yan-Hua WU Gen-Cheng XU Shao-Fen |
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| Abstract: | AIM: To study the changes of monoamines in ventrolatoral periaqueductal gray of rat brain before and after electroacupuncture (EA) analgesia (EAA) was enhanced by fenfluramine (Fen), a 5-hydroxytrypta-mine (5-HT) releaser. METHODS: Monoamines were collected by in vivo microdialysis and measured by HPLC connected with electrochemical detector. RESULTS: The level of norepinephrine (Nor) after EA was decreased ( P < 0.05 vs NS group). The contents of 5-HT, 5-hydroxyindol acetic acid (5-HIAA), dopamine (DA), and homovanillic acid (HVA) in periaqueductal gray dialysate were increased (P<0.05 vs NS group). When Fen was combined with EA, the level of 5-HT and 5-HLAA were further increased (P < 0.05 vs NS EA group). There was no obvious change of Nor, DA, and HVA. CONCLUSION: Fen potentiating EAA may be related to further activation of serotoninergic system. |
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| Keywords: | fenfluramine biogenic monoamines electroacupuncture microdialysis high pressure liquid chromatography electrochemistry periaqueductal gray |
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