| 原发性胆汁性肝硬化患者外周血CD4+CD28-T细胞和CD4+CD25+T细胞亚群变化及意义 |
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| 引用本文： | 汪群英,徐芸.原发性胆汁性肝硬化患者外周血CD4+CD28-T细胞和CD4+CD25+T细胞亚群变化及意义[J].现代预防医学,2010,37(6). |
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| 作者姓名： | 汪群英 徐芸 |
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| 作者单位： | 郑州大学第一附属医院消化内科,郑州,450052 |
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| 基金项目： | 河南省教育厅科技攻项目 |
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| 摘 要： | 目的]探讨原发性胆汁性肝硬化(PBC)患者外周血CD4+CD28-T细胞和CD4+CD25+调节性T细胞亚群的变化及意义。方法]入选病例为我院从2006年6月到2008年12月共59例原发性胆汁性肝硬化患者(活动期36例、稳定期23例),同时以30例健康体检者为对照,借助双色荧光标记技术对外周血CD4+CD28-T细胞和CD4+CD25+占CD4+T细胞比例进行流式细胞术测定。结果]活动期PBC患者外周血CD4+CD25+细胞比例(1.66±0.83)%低于稳定期(2.53±1.06)%和正常组(4.06±2.36)%(P﹤0.05);而CD4+CD28-细胞比例(4.15±1.89)%则高于稳定组(3.66±0.7)%和正常组(1.54±0.99)%(P﹤0.05)。结论]活动期PBC患者外周血CD4+CD25+T细胞比例减少而CD4+CD28-T细胞比例升高,CD4+CD25+比例降低可能使外周免疫耐受失去平衡,参与了PBC疾病的发生发展。
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| 关 键 词： | 原发性胆汁性肝硬化(PBC) T淋巴细胞 T淋巴细胞亚群 自身免疫 |
SIGNIFICANCE AND CHANGES OF CD4+CD28-T CELLS AND CD4+CD25+ REGULATORY CELLS SUBSETS IN PBMC OF PRIMARY BILIARY CIRRHOSIS PATIENTS |
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| WANG Qun-ying,XU Yun.SIGNIFICANCE AND CHANGES OF CD4+CD28-T CELLS AND CD4+CD25+ REGULATORY CELLS SUBSETS IN PBMC OF PRIMARY BILIARY CIRRHOSIS PATIENTS[J].Modern Preventive Medicine,2010,37(6). |
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| Authors: | WANG Qun-ying XU Yun |
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| Affiliation: | WANG Qun-ying,XU Yun. (The First Affiliated Hospital,Zhengzhou 450052,China) |
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| Abstract: | Objective] To investigate the significance and changes of CD4+CD28-T cell and CD4+CD25+ regulatory T cell (Treg) subsets in primary biliary cirrhosis patients (PBC). Methods] 59 (36 in active stage and 23 in stage) patients with PBC were recruited in this study, 30 health people served as the control group. The proportions of peripheral CD4+CD28-T cells and CD4+CD25+Treg cells were detected by flow cytometry. Results] The proportions of CD4+CD25+T cells detected were significantly lower in active stage((... |
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| Keywords: | CD4 CD28 CD25 |
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