| The Association between Polymorphism of TNF-α Gene and Hypertensive Disorder Complicating Pregnancy |
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| 引用本文： | 赵茵,夏曙,邹丽.The Association between Polymorphism of TNF-α Gene and Hypertensive Disorder Complicating Pregnancy[J].华中科技大学学报(医学英德文版),2007,27(6):729-732. |
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| 作者姓名： | 赵茵 夏曙 邹丽 |
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| 作者单位： | Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430022 China，Wuhan 430030 China，Wuhan 430022 China |
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| 摘 要： | To study whether the development of hypertensive disorder complicating pregnancy is associated with -308G→A, -850C→T mutation at promoter of TNF-α gene, the -308G→A, -850C→T polymorphism was examined in patients and healthy pregnant women by PCR-RFLP technique. The frequencies of genotype and allele were compared between the two groups. The re- sults showed that with -308G→A polymorphism distribution, the allele frequency of TNF2 and the frequency of the genotype TNF2/1 in the patient group was significantly higher in the patient group than in control group (P<0.05). A significant difference in genotype distribution of -850C→T poly- morphism was observed between the two groups. The allele frequencies of T in patient group was higher in the control group as compared with the patient group. The frequencies of CT and TT genotypes were lower in the patient group. It is concluded that the TNF2 allele of -308 is associated with the occurrence of hypertensive disorder complicating pregnancy, while T allele of -850 may be the protective factor against the development of the disease. TNF2/1 CC may be susceptibility genotype of hypertensive disorder complicating pregnancy.
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| 关 键 词： | TNF-α hypertensive disorder complicating pregnancy gene polymorphism |
| 收稿时间： | 2007-09-29 |
The association between polymorphism of TNF-α gene and hypertensive disorder complicating pregnancy |
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| Zhao Yin,Xia Shu,Zou Li.The association between polymorphism of TNF-α gene and hypertensive disorder complicating pregnancy[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2007,27(6):729-732. |
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| Authors: | Zhao Yin Xia Shu Zou Li |
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| Affiliation: | Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. yinzily@126.com |
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| Abstract: | To study whether the development of hypertensive disorder complicating pregnancy is associated with -308G-->A, -850C-->T mutation at promoter of TNF-alpha gene, the -308G-->A, -850C-->T polymorphism was examined in patients and healthy pregnant women by PCR-RFLP technique. The frequencies of genotype and allele were compared between the two groups. The results showed that with -308G-->A polymorphism distribution, the allele frequency of TNF2 and the frequency of the genotype TNF2/1 in the patient group was significantly higher in the patient group than in control group (P<0.05). A significant difference in genotype distribution of -850C-->T polymorphism was observed between the two groups. The allele frequencies of T in patient group was higher in the control group as compared with the patient group. The frequencies of CT and TT genotypes were lower in the patient group. It is concluded that the TNF2 allele of -308 is associated with the occurrence of hypertensive disorder complicating pregnancy, while T allele of -850 may be the protective factor against the development of the disease. TNF2/1 CC may be susceptibility genotype of hypertensive disorder complicating pregnancy. |
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