清热凉血化瘀方联合阿替普酶静脉溶栓治疗急性脑梗死的疗效研究

目的:探讨清热凉血化瘀方联合阿替普酶静脉溶栓治疗急性脑梗死的治疗效果。方法:选取2014年6月至2015年12月黄骅市人民医院收治的急性脑梗死患者108例,随机分为观察组和对照组,每组54例。对照组患者给予阿替普酶静脉溶栓等常规治疗,观察组在此基础上加服清热凉血化瘀方。比较2组患者治疗前及治疗后5 d、10 d的美国国立卫生研究院脑卒中量表(NIHSS)评分及Barthel指数,并比较2组的住院天数及临床疗效。结果:2组治疗前的基线资料、NIHSS评分及Barthel指数比较,差异无统计学意义(P 0. 05),具有可比性。观察组治疗后5 d、10 d的NIHSS评分均显著低于同期对照组,差异有统计学意义(均P 0. 05)。观察组治疗后10 d的Barthel指数高于同期对照组,差异有统计学意义(P0. 05)。观察组住院时间低于对照组,差异有统计学意义(P 0. 05)。观察组总有效率高于对照组,差异有统计学意义(P 0. 05)。结论:清热凉血化瘀方联合阿替普酶静脉溶栓治疗急性脑梗死的疗效显著,可明显加快患者的神经功能恢复,缩短住院时间。

Study on Clinical Efficacy of Qingre Liangxue Huayu Decoction Combined with Alteplase Intravenous Thrombolysis on Acute Cerebral Infarction

To investigate the clinical efficacy of Qingre Liangxue Huayu Decoction combined with alteplase intravenous thrombolysis on acute cerebral infarction.Methods:A total of 108 patients with acute cerebral infarction treated in Huanghua People''s Hospital from June 2013 to December 2015 were selected and divided into observation group and the control group,with 54 cases in each group.Patients in the control group were given alteplase intravenous thrombolysis.Based on the same treatment,patients in observation group were given Qingre Liangxue Huayu Decoction.National Institutes of Health Stroke Scale (NIHSS) score and Barthel index were compared between 2 groups before and at the 5th day,10th day after treatment.The hospitalization days and clinical efficacy were compared between the 2 groups.Results:There were no significant differences in the baseline data,NIHSS score and Barthel index before treatment between the 2 groups (P>0.05).The NIHSS score in the observation group was significantly lower than that in the control group at the 5th day,10th day after treatment,and the difference was statistically significant (P<0.05).The Barthel index in the observation group was significantly higher than that in the control group at the 10th day after treatment,and the difference was statistically significant (P<0.05).The hospitalization days of observation group was significantly less than that of control group,and the difference was statistically significant (P<0.05).The clinical efficacy and total effective rate of the observation group were significantly better than the control group,and the difference was statistically significant (P<0.05).Conclusion:Qingre Liangxue Huayu Decoction combined with alteplase intravenous thrombolysise had obvious curative effect on acute cerebral infarction,and it could significantly accelerate the recovery of neurological function and shorten the hospitalization time,which is worthy of clinical application.