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| α-硫辛酸-(13-生物素酰胺基-4,7,10-三氧十三烷基)酰胺的合成研究 | |
| 引用本文： | 徐常龙,曹小华,严平,柳闽生,张爱东.α-硫辛酸-(13-生物素酰胺基-4,7,10-三氧十三烷基)酰胺的合成研究[J].化学试剂,2011,33(4):293-296. |
| 作者姓名： | 徐常龙 曹小华 严平 柳闽生 张爱东 |
| 作者单位： | 1. 九江学院生命科学学院,江西,九江,332000 2. 南京晓庄学院化学系,江苏,南京,210017 3. 华中师范大学农药与化学生物学教育部重点实验室,湖北,武汉,430079 |
| 基金项目： | 国家自然科学基金资助项目(20672043); 江西省自然科学基金资助项目(2009GQH0053); 江西省教育厅科技项目(GJJ10626); 九江学院立项课题(09kj4) |
| 摘 要： | 利用α-硫辛酸、生物素、长醚链二胺等原料,用柱色谱进行纯化和分离,设计合成了标题化合物,并用1HNMR、GC-MS、IR等方法对中间体及目标产物的分子结构进行了表征.通过改变生物素分子中的侧链部分,可合成不同种类的生物素衍生物,增加了牛物素-亲合素/链霉亲合素/中性亲合素自组装膜体系的材料的种类,此自组装膜体系在分子器... |
| 关 键 词： | 生物素 α-硫辛酸-(13-生物素酰胺基-4 7 10-三氧十三烷基)酰胺 自组装膜 合成 |
Synthesis of thioctic-(13-biotinoylamido-4,7,10-trioaxatridecaneamine)amide |
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| XU Chang-long,CAO Xiao-hua,YAN Ping,LIU Min-sheng,ZHANG Ai-dong.Synthesis of thioctic-(13-biotinoylamido-4,7,10-trioaxatridecaneamine)amide[J].Chemical Reagents,2011,33(4):293-296. | |
| Authors: | XU Chang-long CAO Xiao-hua YAN Ping LIU Min-sheng ZHANG Ai-dong |
| Affiliation: | XU Chang-long1,CAO Xiao-hua1,YAN Ping1,LIU Min-sheng*2,ZHANG Ai-dong3(1.College of Life Science,Jiujiang University,Jiujiang 332000,China,2.Department of Chemistry,Xiaozhuang University,Nanjing 210017,3.Key Laboratory of Pesticide & Chemical Biology of Ministry of Education,Central China Normal University,Wuhan 430079,China) |
| Abstract: | Thioctic-(13-biotinoylamido-4,7,10-trioaxatridecaneamine)amide were synthesized by thioctic acid,diamine with ether linkage and biotin.The molecular structures of the intermediates and the target compounds were confirmed by 1HNMR,GC-MS and FT-IR.All kinds of biotinylated molecules can be synthesized by change the side of biotin.Thus applications and kinds of the material of biotin-avidin/streptavidin/neutravidin assembled systems were increased.This assembled systems have many applications in the fields. |
| Keywords: | biotin thioctic-(13-biotinoylamido-4 7 10-trioaxatridecaneamine)amide self-assembled monolayers synthesis |
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