| 肝豆状核变性基因连锁图谱的研究 |
| |
| 引用本文： | 徐评议,梁秀龄,刘焯霖.肝豆状核变性基因连锁图谱的研究[J].中山大学学报(医学科学版),1995(Z1). |
| |
| 作者姓名： | 徐评议 梁秀龄 刘焯霖 |
| |
| 作者单位： | 中山医科大学附属第一医院神经科 |
| |
| 摘 要： | 为寻找适于中国人Ｗｉｌｓｏｎ氏病（ＷＤ）基因连锁分析的遗传标记及制定ＷＤ基因所在区域的遗传图谱，我们应用Ｄ１３ｑ１４－２１区域４个ＤＮＡ标记对７５名无亲缘关系个体及９个ＷＤ家系成品进行连锁分析。结果发现４个ＤＮＡ标记中３个标记等位片段与白种人相同而杂合率相异，其中２个ＤＮＡ标记Ｄ１３Ｓ３１，Ｐ１２３Ｍ１．８与ＷＤ基因存在紧密连锁关系。其遗传顺序为：着丝点－Ｒｂ－Ｄ１３Ｓ３１－ＷＮＤ。
|
| 关 键 词： | 肝豆状核变性／遗传学 限制性片区长度多态性，染色体图 |
TJE STIDY OF MAP OF WILSON'S DISEASEGENE BY LINKAGE ANALYSIS |
| |
| Xu Pingyi,Liang Xiuling,Liu Zhuolin.TJE STIDY OF MAP OF WILSON'S DISEASEGENE BY LINKAGE ANALYSIS[J].Journal of Sun Yatsen University(Medical Sciences),1995(Z1). |
| |
| Authors: | Xu Pingyi Liang Xiuling Liu Zhuolin |
| |
| Abstract: | n this paper , to obtain DNA markers more closely linked to Wilson's disease gene (WD) in Chinese and constructed a genetic map of DNA markers within D13q14-21 which will refine the location of WD , the authors analyzed the segregation of 4 DNA markers within D13q14-21 in 75 unrelated normal Chinese individuals and members of 9 Chinese families with WD. The DNA analysis revealed the polymorphic alleles of 3 markers were the same in Chinese as in Caucasians but the allele frequencies were quite different , we confirmed a tight linkage between WD gene and 2 markers D13S31 , Rb. The genetic order was as follows : centromere - Rb - D13S31 -WND. |
| |
| Keywords: | epatolenticular degeneration/genetics restriction fragment length polytnorphism chromosome mapping |
| 本文献已被 CNKI 等数据库收录！ |
