注射用泮托拉唑钠治疗上消化道出血的临床观察

目的：对比观察国产新药注射用泮托拉唑钠和奥美拉唑粉剂治疗上消化道出血的临床疗效及副作用。方法：采用临床多中心随机单盲对照法。结果：两组在临床症状和实验室检查方面,无显著性差异（Ｐ〉０．０５）。副作用发生率分别为２１．９％和２９．２％（Ｐ〈０．０５）,均无因药物不良反应中断治疗的患者。结论：泮托拉唑钠和奥美拉唑疗效相当,不良反应轻微,国产泮托拉唑粉针剂治疗上消化道出血有效而安全。

PANTOLOC VS. OMEPRAZOLE IN UPPER GASTROINTESTING BLEEDING

OBJECTIVE: The patients with Upper Gastrointesting Bleeding participated in a multicenter,randomized, singleblind trial for comparison of the effectiveness and side effects between pantoloc (Pan)injection and Omeprazole(Ome). METHODS: 68 patients received Pan and 69 received Ome for 5 days. The effectiveness of the drugs was evaluated by clinical symptoms and laboratory tests. At the same time, possible side effects were recorded. RESULTS: Both groups improved significantly in terms of clinical symptoms and laboratory tests after 5 days of the treatment with no statistically significant differences (P>0.05). The side effects in the two groups were 21.9% and 29.2% separately(P>0.05)without withdrawal .CONCLUSION: Pan injection is as effective as Ome in Upper Gastrointesting Bleeding. And it causes little systemic effects. Pan is effective and safe.