Mechanisms of oxidant-induced changes in erythrocytes |
| |
| Authors: | J R Hatherill G O Till P A Ward |
| |
| Affiliation: | (1) Radian Corporation, 2250 E. Imperial Hwy., Suite 140, 90245 El Segundo, CA, USA;(2) Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA |
| |
| Abstract: | There is an increasing body of experimental studies demonstrating the toxic effects of oxygen-derived free radicals. Evidence supports an important role for free radicals in ischemic injuries, inflammation, and chemical-induced tissue injury. Free radicals are involved in normal biochemical processes like oxidative reduction and cellular metabolism; however, they also mediate disease processes. The participation of oxygen free radicals in lysis of red cells is important in some situations of intravascular hemolysis. This article will review neutrophil-derived oxygen free radicals, emphasizing: (1) their effects on the erythrocyte and (2) how these effects may be attenuated.Supported in part by NIH Grants HL-31963, GM-28499, and GM-29507. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
