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Magnetically Powered Immunogenic Macrophage Microrobots for Targeted Multimodal Cancer Therapy (Small 42/2023) |
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| Authors: | Yangyang Li Zhaoqing Cong Leiming Xie Songsong Tang Chunyu Ren Xiqi Peng Daitian Tang Fangchen Wan Hong Han Xueji Zhang Wei Gao Song Wu |
| Affiliation: | 1. Institute of Urology, The Third Affiliated Hospital of Shenzhen University, Shenzhen, 518000 P. R. China
Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen, 518000 P. R. China;2. Institute of Urology, The Third Affiliated Hospital of Shenzhen University, Shenzhen, 518000 P. R. China Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen, 518000 P. R. China Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125 USA;3. Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, Pasadena, CA, 91125 USA;4. School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen, 518060 P. R. China;5. Institute of Urology, The Third Affiliated Hospital of Shenzhen University, Shenzhen, 518000 P. R. China Shenzhen Following Precision Medical Research Institute, Luohu Hospital Group, Shenzhen, 518000 P. R. China South China Hospital, Health Science Center, Shenzhen University, Shenzhen, 518116 P. R. China |
| Abstract: | Motile microrobots open a new realm for disease treatment. However, the concerns of possible immune elimination, targeted capability and limited therapeutic avenue of microrobots constrain its practical biomedical applications. Herein, a biogenic macrophage-based microrobot loaded with magnetic nanoparticles and bioengineered bacterial outer membrane vesicles (OMVs), capable of magnetic propulsion, tumor targeting, and multimodal cancer therapy is reported. Such cell robots preserve intrinsic properties of macrophages for tumor suppression and targeting, and bioengineered OMVs for antitumor immune regulation and fused anticancer peptides. Cell robots display efficient magnetic propulsion and directional migration in the confined space. In vivo tests show that cell robots can accumulate at the tumor site upon magnetic manipulation, coupling with tumor tropism of macrophages to greatly improve the efficacy of its multimodal therapy, including tumor inhibition of macrophages, immune stimulation, and antitumor peptides of OMVs. This technology offers an attractive avenue to design intelligent medical microrobots with remote manipulation and multifunctional therapy capabilities for practical precision treatment. |
| Keywords: | bacterial outer membrane vesicles immunotherapies macrophage-based microrobots magnetic propulsion multimodal therapies |
