瞬时波强技术评价系统性红斑狼疮患者心血管系统功能

目的 探讨瞬时波强(WI)技术评估系统性红斑狼疮(SLE)患者心血管系统损害的临床应用价值.方法 应用WI技术检测30例SLE患者(SLE组)和30名健康对照者(正常对照组)的瞬时加速度波强峰值W1、瞬时减速度波强峰值W2、负向波面积NA、心电图R波至W1波顶点时间R-W1、W1与W2的时间间隔W1-W2、血管僵硬度指数β、血管压力应变弹性系数Eρ、脉搏波传导速度PWVβ、血管顺应性AC等.结果 SLE组患者心率为(80.09±13.80)次/min,较正常对照组的(68.29±7.16)次/min增快,差异有统计学意义(t=-4.249,P=0.000);SLE组患者收缩压为(121.39±21.76) mm Hg(1 mm Hg=0.133 kPa),较正常对照组的(11.81±8.92)mm Hg高,差异有统计学意义(t=-2.278,P=0.026);SLE组患者年龄、舒张压、脉压差、体重指数、体表面积均较正常对照组增高,但差异均无统计学意义.SLE组W2为(1.11±0.76)×103 mmHg·m/s3,W1-W2为(243.15±25.83) ms,(W1-W2)/t为0.19±0.04,均较正常对照组的(1.39±0.49)×103 mmHg·m/s3、(264.17±15.94) ms、0.24±0.04降低,差异均有统计学意义(t值分别为-2.546、3.889、-5.003,P均<0.05);SLE组患者β为7.23±2.06,Eρ为(99.72±49.68)kPa,PWVβ为(6.10±1.55) m/s,均较正常对照组的5.67±1.37、(69.14±15.79) kPa、(5.13±0.58) m/s增高,且差异均有统计学意义(t值分别为-2.61、-3.101、-3.254,P均<0.05);SLE组W1、NA较正常对照组增高,R-W1较正常对照组降低,但差异均无统计学意义.结论 WI技术能够早期发现系统性红斑狼疮的心血管系统损伤,为临床早期诊断、早期干预治疗提供客观的参数依据.

Evaluation of cardiovascular system function in patients with systemic lupus erythematosus by wave intensity

Objective To investigate the clinical value of wave intensity technique for evaluating the damage of cardiovascular function in patients with systemic lupus erythematosus（SLE）.Methods Thirty-three patients with SLE（SLE group）and 30 normal person（normal group） were detected by wave intensity.The following parameters were obtained,including instantaneous acceleration wave intensity（W1）,instantaneous deceleration wave intensity（W2）,negative wave area（NA）,the time between electr-ocardiogram R wave apex and W1 wave apex（R-W1）,internal time between W1 and W2 wave（W1-W2）,stiffness paramet（β）,elastic coefficient（Eρ）,pulse wave velocity（PWVβ）,compliance（AC）.Results The heart rate in SLE group was significantly faster than that in the normal group（80.09±13.80）/min vs（68.29±7.16）/min,t=-4.249,P=0.000];systolic pressure in SLE group was significantly higher than that in normal group（121.39±21.76） mm Hg vs（11.81±8.92） mm Hg,1 mm Hg=0.133 kPa,t=-2.278,P=0.026].For the patients age,diastolic pressure,pressure difference,body mass index and body surface area,there were no significant differences between two groups.W2,W1-W2 and（W1-W2）/t in SLE group were all lower than that in normal group （1.11±0.76）×103 mm Hg·m/s3 vs（1.39±0.49）×103mm Hg·m/s3,（243.15±25.83） ms vs（264.17±15.94） ms,（0.19±0.04） vs（0.24±0.04）],and the differences were significant（t=-2.546,3.889,-5.003,all P0.05）;β,Eρ and PWVβ in SLE group were all higher than that in normal group（7.23±2.06） vs（5.67±1.37）,（99.72±49.68） kPa vs（69.14±15.79） kPa,（6.10±1.55） m/s vs（5.13±0.58） m/s],and the differences were significant（t=-2.61,-3.101,-3.254, all P0.05）.W1 and NA in SLE group were higher than that in normal group,and R-W1 in SLE group was lower than that in normal group,but the differences were not significant.Conclusion Wave intensity technique can detect the damage in cardiovascular system earlier and provide objective evidence for early diagnosis and intervention treatment.