短期胰岛素泵治疗对初诊2型糖尿病患者胰岛β细胞功能的影响

目的观察短期应用胰岛素泵治疗对初诊2型糖尿病患者血糖、胰岛β细胞功能和胰岛素敏感性的影响。方法用胰岛素泵对72例初诊2型糖尿病患者进行2周的持续皮下胰岛素输注（CSII），观察并记录治疗前后空腹血糖（FPG）及餐后2h血糖（2hPG）、糖化血红蛋白Alc（HbAlc）、空腹胰岛素（FINS）、餐后2h胰岛素（2hINS）、胰岛素分泌指数（HOMA—β）、早期胰岛素分泌指数胰岛素抵抗指数（HOMA—IR）。计算胰岛素及葡萄糖曲线下面积（AUCI，AUCG）。结果CSII治疗能快速稳定控制血糖，治疗2周后FINS及HOMA—β明显上升，HOMA—IR明显下降（P〈0．01）。结论短期CSII治疗对2型糖尿病有快速稳定血糖、改善胰岛β细胞功能和降低胰岛素抵抗的作用。

Effect of Short-term Continuous Subcutaneous Insulin Infusion Treatment on Beta-cell Function and Insulin Resistance in Type 2 Diabetic Patient

Objective To observe the effect of short-term continuous subcutaneous insulin infusion （ CSII ） on blood glucose, betacell function and insulin resistance in patients with newly-diagnosed type 2 diabetes mellitus. Methods Seventy-two patients with newly-diagnosed type 2 diabetes mellitus receiving two weeks of CSII therapy were analyzed . The levels of the fasting plasma glucose （FPG）,2 hours postpradial glucose （2hPG）, and glycosylated hemoglobin Alc（ HbAlc ）, fast insulin （FINS）,2 hours postpradial insulin and insulin secretion indexes （ HOMA-β ） and insulin resistance index （ HOMA-IR ） were determined and compared before and after CSII. Results The level of blood glucose was well stably controlled by CSII. The levels of FINS, HOMA-β were increased significantly two weeks after intensive treatment with CSII. The HOMA-IR were decreased significantly. Conclusion Short-term CSII intensive treatment can stably control the level of blood sugar, improve the function of beta-cell and reduce the resistance to insulin in type 2 diabetic patients.