| 姜黄素对大鼠动脉粥样硬化内皮细胞损伤的影响 |
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| 引用本文： | 丁奇峰,陈志强,黄怀鹏,张秀君,方敬,范焕芳.姜黄素对大鼠动脉粥样硬化内皮细胞损伤的影响[J].中药药理与临床,2005,21(5):10-12. |
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| 作者姓名： | 丁奇峰 陈志强 黄怀鹏 张秀君 方敬 范焕芳 |
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| 作者单位： | 1. 河北医科大学中西医结合研究所,石家庄,050017
2. 神威药业有限公司,石家庄,051430 |
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| 摘 要： | 目的:研究姜黄素对动脉粥样硬化(AS)内皮细胞损伤的保护作用.方法:复制实验性大鼠AS模型,测定超氧化物歧化酶(SOD)活性和丙二醛(MDA)、前列环素(PGI2)、血栓素A2(TXA2)含量.采用免疫组化、RT-PCR方法检测AS斑块细胞间粘附分子-1(ICAM-1)和ICAM-1mRNA的表达水平.结果:姜黄素可使血清MDA及血浆TXB2(TXA2)含量降低,6-酮-前列腺素F1a(PGI2)升高,并使AS斑块ICAM-1表达水平降低.结论:姜黄素抗AS作用的机制可能与其抗氧化、抗血栓及抗粘附作用等保护血管内皮细胞功能密切相关.
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| 关 键 词： | 姜黄素 内皮细胞 |
The influence of total curcumin on the damage of rat atheromatous endothelial cells |
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| Ding Qifeng,Chen Zhiqiang,Huang Huaipeng,Zhang Xiujun,Fang Jing,Fan Huanfang.The influence of total curcumin on the damage of rat atheromatous endothelial cells[J].Pharmacology and Clinics of Chinese Materia Medica,2005,21(5):10-12. |
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| Authors: | Ding Qifeng Chen Zhiqiang Huang Huaipeng Zhang Xiujun Fang Jing Fan Huanfang |
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| Affiliation: | 1.Institute of Integration of TCM-WM, Hebei Medical University, Shijiazhuang 050017; 2. Shinwey Pharmaceutical Co. Ltd, Shijiazhuang 051430 |
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| Abstract: | Objective: To investigate the protective effect of total curcumin to the damage of atheromatous endothelial cell.Method: The experimental atheromatous model of SD rat was duplicated;the activity of maleic dialdehyde(MDA) and the content of superoxide dismutase(SOD),prostacyclin(PGI_2) and thromboxane A_2(TXA_2) were assayed.Immunohistochemical method was adopted to measure the intercellular adhesion molecule 1(ICAM-1) in atheromatous plaque,and the expression of ICAM-1mRNA were detected by RT-PCR.Results: Curcumin can reduce blood serum MDA,the content of plasm TXA_2;raise the content of PGT2.The expression of ICAM-1 was reduced.Conclusion: The mechanism of curcumin anti-atherosclerosis probably due to the function of protecting angio-endothelial cell,anti-oxidation,anti-thrombus and anti-adhesiveness. |
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| Keywords: | ICAM-1 RT-PCR |
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