Validation of Models Predicting Nucleation Rates from Induction Times and Metastable Zone Widths |
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Authors: | Somchai Maosoongnern Adrian E Flood |
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Affiliation: | School of Energy Science and Engineering, Vidyasirimedhi Institute of Science and Technology, Department of Chemical and Biomolecular Engineering, Rayong, Thailand |
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Abstract: | Three approaches for estimation of nucleation rates from induction time and metastable zone width (MSZW) were validated based on directly measured nucleation rates for paracetamol in ethanol. To quantitatively predict nucleation kinetics using Kubota's methods it is necessary to know the minimum detectable number concentration of nuclei. This was found by determination of light transmission of a series of diluted suspensions of newly nucleated crystals where the size had already been assessed by optical reflection measurement (ORM). The measured nucleation rates strongly depended on both temperature and supersaturation. The Nyvlt method predicted nucleation rates in this system reasonably well; however, it gave slightly low estimates for all temperatures. The methods of Kubota provided nucleation rates that were low by an order of magnitude. |
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Keywords: | Metastable zone width Nucleation induction time Paracetamol Primary nucleation rate |
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