| Fas/FasL系统与慢性心力衰竭 |
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| 引用本文： | 吕晋琳,杨丽霞.Fas/FasL系统与慢性心力衰竭[J].国际病理科学与临床杂志,2008,28(2):7-125. |
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| 作者姓名： | 吕晋琳 杨丽霞 |
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| 作者单位： | 成都军区昆明总医院心血管内科,昆明,650032 |
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| 摘 要： | Fas和FasL是细胞表面蛋白，与机体的分化发育、免疫调控密切相关。Fas/FasL系统在慢性心力衰竭的发生发展过程中参与免疫炎性反应、诱导心肌细胞凋亡、促进心肌细胞肥大增生、加剧心肌缺血再灌注损伤等过程。
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| 关 键 词： | Fas FasL 慢性心力衰竭 |
| 文章编号： | 1673-2588(2008)02-0122-04 |
| 收稿时间： | 2007-7-6 |
| 修稿时间： | 2007年7月6日 |
Fas/FasL system and chronic heart failure |
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| L Jin-jin,YANG Li-xia.Fas/FasL system and chronic heart failure[J].Journal of International Pathology and Clinical Medicine,2008,28(2):7-125. |
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| Authors: | L Jin-jin YANG Li-xia |
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| Affiliation: | L(U) Jin-jin,YANG Li-xia |
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| Abstract: | Chronic heart failure (CHF) is the common manifestation of every kinds of end-stage cardiovascular diseases. Many cytokines attend the course of the clinical syndrome in a complex interaction. Fas and FasL are cell surface protein which are closely related to the immune regulation，devolepment and differentiation of body. There are certain relations between Fas/FasL system and CHF, such as participating in immunal reaction，inducing apoptosis of cardiomyocytes，promoting the hypertrophy of cardiomyocytes and aggravating myocardial ischemic-reperfusion injury. |
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| Keywords: | Fas FasL chronic heart failure |
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