Increased risk of Kawasaki disease in children with common allergic diseases |
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| Affiliation: | 1. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan;2. Department of Pediatrics, College of Medicine, China Medical University, Taichung, Taiwan;3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;4. Department of Public Health, China Medical University, Taichung, Taiwan;5. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan;6. Department of Radiology, China Medical University Hospital, Taichung, Taiwan;7. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan;8. Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan;9. Department of Health Promotion and Health Education, National Taiwan Normal University, Taipei, Taiwan;1. Toxicology Unit, Department of Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Campus Elviña s/n, 15071-A Coruña, Spain;2. Medical Technology, Faculty of Medicine, University of Valparaíso, Blanco 1911, Valparaíso, Chile;1. Department of Paediatric Allergy, School of Life Course Sciences, King''s College London, London, United Kingdom;2. Paediatric Allergy, Guy''s and St Thomas'' Hospitals NHS Foundation Trust, London, United Kingdom;3. Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, United Kingdom;1. Campus Atlacomulco, Autonomous University of the State of Mexico, Atlacomulco, Mexico;2. Psychology Department, Iberoamerican University, Mexico City, Mexico;3. Laboratory of Animal Behavior, Faculty of Sciences, Autonomous University of the State of Mexico, Atlacomulco, Mexico;4. Department of Biology, Faculty of Sciences, Autonomous University of Madrid, Madrid, Spain;1. Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA |
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| Abstract: | PurposeGrowing evidence reveals a link between Kawasaki disease (KD) and allergic diseases. This population-based case-control study is to investigate the onset of allergic diseases in children and the associated risks of KD.MethodsFrom 1996 to 2008, 2748 children with KD and 10,656 randomly selected controls were enrolled. Odds ratios of KD were calculated for the association with pre-existing allergic diseases.ResultsThe children with a single allergic disease had an increased risk of KD, with adjusted odds ratios of having KD of 1.82 for urticaria (95% confidence interval CI], 1.54–2.14), 1.44 for allergic rhinitis (95% CI, 1.23–1.70), and 1.22 for atopic dermatitis (95% CI, 1.06–1.39). The adjusted odds ratios increased with the number of concurrent allergic diseases, from 1.61 (95% CI, 1.43–1.82) for those with only one allergic disease to 1.71 (95% CI, 1.48–1.98) for those with at least two allergic diseases. The children who made two or more medical visits for associated allergic diseases per year had an increased risk of KD.ConclusionsChildren with onset of allergic diseases were at increased risk for KD, and the increased risk was associated with the cumulative effect of concurrent allergic diseases and frequency of seeking medical care. |
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| Keywords: | Allergic conjunctivitis Allergic rhinitis Asthma Atopic dermatitis Kawasaki disease Urticaria |
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