Architectural self-construction in nature and chemical synthesis |
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Authors: | Sorensen Erik J |
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Affiliation: | Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-123, La Jolla, CA 92037, USA. sorensen@scripps.edu |
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Abstract: | The chemistry of squalene oxide (1) exemplifies that architectural complexity can be encoded in the structures of relatively simple, polyunsaturated molecules. When the concept of architectural self-construction is an integral part of the design of a chemical synthesis, powerful strategies can be uncovered. this article addresses studies which showed that polyunsaturated, 19-membered ring carbocycle contains all of the molecular information that is required to give the stereochemically complex polycyclic architecture of the cytotoxic natural product FR182877. |
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