| 霜制对苦杏仁中苦杏仁苷在大鼠尿液中的代谢与排泄影响 |
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| 引用本文： | 付志玲,郑晓晖,房敏峰.霜制对苦杏仁中苦杏仁苷在大鼠尿液中的代谢与排泄影响[J].中成药,2011,33(7):1202-1205. |
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| 作者姓名： | 付志玲 郑晓晖 房敏峰 |
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| 作者单位： | 西部资源生物与现代生物技术教育部重点实验室，西北大学生命科学学院，陕西西安710069 |
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| 基金项目： | 陕西省中医管理局基金资助项目(陕中医发20072507) |
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| 摘 要： | 目的 探讨霜制对苦杏仁中苦杏仁苷在大鼠尿液中的代谢与排泄影响.方法 将SD大鼠分别注射苦杏仁苷、灌胃苦杏仁生品及霜制品水煎液,于不同时间段收集尿液,HPLC测定尿液中马尿酸、苦杏仁苷及其代谢产物野樱苷,LCMSn鉴定代谢产物的结构.结果 苦杏仁苷注射给药后主要以原型排泄,马尿酸质量分数无明显变化；苦杏仁生品与霜制品灌胃给药后主要以代谢产物野樱苷的形式排泄,马尿酸质量分数有显著增长,且霜制后野樱苷的排泄时间延迟.结论 霜制对苦杏仁中苦杏仁苷的排泄有较大影响.
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| 关 键 词： | 苦杏仁 霜制 代谢 高效液相色谱-质谱联用 |
Effect of defatted method on metabolism and excretion of bitter almond in rat urine |
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| FU Zhi-ling
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ZHENG Xiao-hui
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FANG Min-feng.Effect of defatted method on metabolism and excretion of bitter almond in rat urine[J].Chinese Traditional Patent Medicine,2011,33(7):1202-1205. |
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| Authors: | FU Zhi-ling ZHENG Xiao-hui FANG Min-feng |
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| Affiliation: | FU Zhi-ling,ZHENG Xiao-hui,FANG Min-feng(Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,The College of Life Sciences,Northwest University,Xi'an 710069,China) |
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| Abstract: | AIM To explore the processing influence of removal of oil on metabolism and excretion of bitter almond in rat urine.METHODS Six SD rats were given the injection of amygdalin,other six SD rats took the perfusion of the extract of bitter almond,the third group of six SD rats took the extract of defatted bitter almond.Sample of these rats' urine was collected at various time intervals and contents of amygdalin,hippuric acid and prunasin analyzed on HPLC.LC-MS was applied to the structure analysis.RESULTS After... |
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| Keywords: | bitter almond processing metabolism LC-MSn |
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