Uptake of fatty acids by the developing rat brain |
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Authors: | Gregory J Anderson William E Connor |
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Affiliation: | (1) Department of Medicine, Division of Endocrinology/Metabolism and Clinical Nutrition, The Oregon Health Sciences University, 97201 Portland, OR |
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Abstract: | Polyunsaturated fatty acids are avidly taken up by the developing rat brain. To explore the specificity of this process, 1-14C]labeled 16∶0, 18∶2n−6, 18∶3n−3, and 22∶6n−3 each were co-injected with 3H]18∶1n−9 into the jugular vein of two-wk-old functionally hepatectomized and shamoperated control rats. The radioactivities
present in the brain, liver and serum were assessed 30 min after injection. Uptake of labeled fatty acids into brain lipids
steadily increased with increasing degree of unsaturation, with more than twice as much uptake of 22∶6n−3 compared to 16∶0.
Phosphatidylcholine was the principal radioactive species in the brain except for animals injected with 1-14C]22∶6n−3, in which more of the label was incorporated into phosphatidylethanolamine. Determination of watersoluble oxidation
products in the brain and serum revealed that the greater uptake of the more unsatrated fatty acids did not result from differences
in rates of degradation. |
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