| 脑创伤后NF-kB的作用及其细胞凋亡的基因调控 |
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| 引用本文： | 赵红念,杨开明.脑创伤后NF-kB的作用及其细胞凋亡的基因调控[J].大理学院学报,2006,5(2):70-72. |
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| 作者姓名： | 赵红念 杨开明 |
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| 作者单位： | 1. 大理学院附属医院脑系科,云南,大理,671000
2. 大理学院基础学院解剖教研室,云南,大理,671000 |
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| 摘 要： | 目的：探讨核因子kB（NF-kB）在脑创伤后的作用及细胞凋亡的调控基因。方法：对近年来有关NF—kB在脑创伤后的作用及细胞凋亡的调控基因的文献进行总结。结果．NF-kB在脑创伤中的作用为双重性，脑创伤后细胞凋亡的调控基因为bcl-2基因家族和Caspase基因家族。结论：NF-kB在脑创伤中是诱导细胞死亡还是促进细胞死亡，还具有分歧，bcl-2基因族和Caspase基因家族在脑创伤中的细胞凋亡起着重要调节作用。
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| 关 键 词： | 脑创伤 NF-kB细胞调亡 基因调控 |
| 文章编号： | 1672-2345(2006)02-0070-03 |
| 收稿时间： | 09 9 2005 12:00AM |
| 修稿时间： | 2005年9月9日 |
The Roles of NF-kB and Genes Regulation of Cells Apoptosis After Traumatic Brain Injury |
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| ZHAO Hong-nian,YANG Kai-ming.The Roles of NF-kB and Genes Regulation of Cells Apoptosis After Traumatic Brain Injury[J].Journal of Dali University,2006,5(2):70-72. |
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| Authors: | ZHAO Hong-nian YANG Kai-ming |
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| Affiliation: | 1.Neurological Department of Affiliated Hospital of Dali University, Dali, Yunnan 671000, China; 2. Anatomic Department of Preclinical Medical College, Dali University, Dali, Yunnan 671000, China |
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| Abstract: | Objective: The role of NF-kB in traumatic brain injury and regulative genes of cell apoptosis after traumatic brain injury were discussed.Method: The recently documents about traumatic brain injury were reviewed.Results: Cytokine of NF-kB have double effects and the regulative genes are bcl-2 and Caspase gene family.Conclusions: There are distractions for the role of NF-kB promote or induce cell to death,and bc1-2 and Caspase gene family play a vital role in cell apoptosis after traumatic brain ingury. |
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| Keywords: | traumatic brain injury NF-kB cell apoptosis gone regulation |
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