| Protective roles of α-lipoic acid in rat model of mitochondrial DNA4834bp deletion in inner ear |
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| 引用本文： | 彭炜,胡钰娟,钟毅,陈蓓,孙宇,杨阳,孔维佳.Protective roles of α-lipoic acid in rat model of mitochondrial DNA4834bp deletion in inner ear[J].华中科技大学学报(医学英德文版),2010,30(4):514-518. |
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| 作者姓名： | 彭炜 胡钰娟 钟毅 陈蓓 孙宇 杨阳 孔维佳 |
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| 作者单位： | Department of Otorhinolaryngology,Union Hospital,Tongii Medical College,Huazhong University of Science and Technology,Wuhan 430022,China |
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| 基金项目： | supported by grants from the State Key Program of National Natural Science of China (No. 30730094);; the National Science & Technology Pillar Program during the Eleventh Five-year Plan Period (No. 2007BAI18B13) |
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| 摘 要： | The protective roles of α-lipoic acid in the rat model of mitochondrial DNA (mtDNA) 4834bp deletion in inner ear were investigated. Forty female Wistar rats at 4 weeks of age were divided into four groups: group A (D-galactose group, n=10), group B (D-galactose+α-lipoic acid group, n=10), group C (α-lipoic acid group, n=10), and group D (control group, n=10). Auditory brainstem response (ABR) was used to detect the hearing threshold. Colorimetry was used to analyze activity of superoxide dismutase (SOD) and...
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| 关 键 词： | α-lipoic acid D-galactose mitochondrial DNA common deletion presbycusis |
| 收稿时间： | 24 December 2008 |
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